Spontaneous Polarization and Cell Guidance on Asymmetric Nanotopography

dc.contributor.authorHerr, Corey
dc.contributor.authorWinkler, Benjamin
dc.contributor.authorZiebert, Falko
dc.contributor.authorAranson, Igor S.
dc.contributor.authorFourkas, John T.
dc.contributor.authorLosert, Wolfgang
dc.date.accessioned2023-09-11T17:02:10Z
dc.date.available2023-09-11T17:02:10Z
dc.date.issued2022-05-11
dc.descriptionPartial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.
dc.description.abstractAsymmetric nanotopography with sub-cellular dimensions has recently demonstrated the ability to provide a unidirectional bias in cell migration. The details of this guidance depend on the type of cell studied and the design of the nanotopography. This behavior is not yet well understood, so there is a need for a predictive description of cell migration on such nanotopography that captures both the initiation of migration, and the way cell migration evolves. Here, we employ a three-dimensional, physics-based model to study cell guidance on asymmetric nanosawteeth. In agreement with experimental data, our model predicts that asymmetric sawteeth lead to spontaneous motion. Our model demonstrates that the nanosawteeth induce a unidirectional bias in guidance direction that is dependent upon actin polymerization rate and sawtooth dimensions. Motivated by this model, an analysis of previously reported experimental data indicates that the degree of guidance by asymmetric nanosawteeth increases with the cell velocity.
dc.description.urihttps://doi.org/10.1038/s42005-022-00889-0
dc.identifierhttps://doi.org/10.13016/dspace/ppne-b7n3
dc.identifier.citationHerr, C., Winkler, B., Ziebert, F. et al. Spontaneous polarization and cell guidance on asymmetric nanotopography. Commun Phys 5, 114 (2022).
dc.identifier.urihttp://hdl.handle.net/1903/30451
dc.language.isoen_US
dc.publisherSpringer Nature
dc.relation.isAvailableAtCollege of Computer, Mathematical & Natural Sciencesen_us
dc.relation.isAvailableAtPhysicsen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.titleSpontaneous Polarization and Cell Guidance on Asymmetric Nanotopography
dc.typeArticle
local.equitableAccessSubmissionNo

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