Current progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018

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dc.contributor.authorMeisel, Jacquelyn S.
dc.contributor.authorNasko, Daniel J.
dc.contributor.authorBrubach, Brian
dc.contributor.authorCepeda-Espinoza, Victoria
dc.contributor.authorChopyk, Jessica
dc.contributor.authorCorrada-Bravo, Héctor
dc.contributor.authorFedarko, Marcus
dc.contributor.authorGhurye, Jay
dc.contributor.authorJavkar, Kiran
dc.contributor.authorOlson, Nathan D.
dc.contributor.authorShah, Nidhi
dc.contributor.authorAllard, Sarah M.
dc.contributor.authorBazinet, Adam L.
dc.contributor.authorBergman, Nicholas H.
dc.contributor.authorBrown, Alexis
dc.contributor.authorCaporaso, J. Gregory
dc.contributor.authorConlan, Sean
dc.contributor.authorDiRuggiero, Jocelyne
dc.contributor.authorForry, Samuel P.
dc.contributor.authorHasan, Nur A.
dc.contributor.authorKralj, Jason
dc.contributor.authorLuethy, Paul M.
dc.contributor.authorMilton, Donald K.
dc.contributor.authorOndov, Brian D.
dc.contributor.authorPreheim, Sarah
dc.contributor.authorRatnayake, Shashikala
dc.contributor.authorRogers, Stephanie M.
dc.contributor.authorRosovitz, M. J.
dc.contributor.authorSakowski, Eric G.
dc.contributor.authorSchliebs, Nils Oliver
dc.contributor.authorSommer, Daniel D.
dc.contributor.authorTernus, Krista L.
dc.contributor.authorUritskiy, Gherman
dc.contributor.authorZhang, Sean X.
dc.contributor.authorPop, Mihai
dc.contributor.authorTreangen, Todd J.
dc.date.accessioned2021-06-15T14:49:18Z
dc.date.available2021-06-15T14:49:18Z
dc.date.issued2018-11-05
dc.description.abstractThe Mid-Atlantic Microbiome Meet-up (M3) organization brings together academic, government, and industry groups to share ideas and develop best practices for microbiome research. In January of 2018, M3 held its fourth meeting, which focused on recent advances in biodefense, specifically those relating to infectious disease, and the use of metagenomic methods for pathogen detection. Presentations highlighted the utility of next-generation sequencing technologies for identifying and tracking microbial community members across space and time. However, they also stressed the current limitations of genomic approaches for biodefense, including insufficient sensitivity to detect low-abundance pathogens and the inability to quantify viable organisms. Participants discussed ways in which the community can improve software usability and shared new computational tools for metagenomic processing, assembly, annotation, and visualization. Looking to the future, they identified the need for better bioinformatics toolkits for longitudinal analyses, improved sample processing approaches for characterizing viruses and fungi, and more consistent maintenance of database resources. Finally, they addressed the necessity of improving data standards to incentivize data sharing. Here, we summarize the presentations and discussions from the meeting, identifying the areas where microbiome analyses have improved our ability to detect and manage biological threats and infectious disease, as well as gaps of knowledge in the field that require future funding and focus.en_US
dc.description.urihttps://doi.org/10.1186/s40168-018-0582-5
dc.identifierhttps://doi.org/10.13016/rzch-h0i5
dc.identifier.citationMeisel, J.S., Nasko, D.J., Brubach, B. et al. Current progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018. Microbiome 6, 197 (2018).en_US
dc.identifier.urihttp://hdl.handle.net/1903/27163
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtSchool of Public Health
dc.relation.isAvailableAtMaryland Institute of Applied Environmental Health
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.subjectMicrobiomeen_US
dc.subjectMetagenomicsen_US
dc.subjectBioinformaticsen_US
dc.subjectBiodefenseen_US
dc.subjectBiothreatsen_US
dc.subjectPathogen detectionen_US
dc.subjectLongitudinal analysisen_US
dc.titleCurrent progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018en_US
dc.typeArticleen_US

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