Inhibiting Degranulation in Immune Cell Signaling Pathways

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dc.contributor.advisorFrauwirth, Kenneth
dc.contributor.authorFadul, Naja
dc.contributor.authorKasica, Zachary
dc.contributor.authorLaurence, Kyeisha
dc.contributor.authorMoy, Stephanie
dc.contributor.authorMurugan, Sindhu
dc.contributor.authorPamala, Chinmayi
dc.contributor.authorRobinson, Morgan
dc.contributor.authorShah, Rohan
dc.contributor.authorShrestha, Mansu
dc.contributor.authorSmith, Marcus
dc.contributor.authorVashi, Bhavya
dc.date.accessioned2020-04-24T14:24:59Z
dc.date.available2020-04-24T14:24:59Z
dc.date.issued2020
dc.description.abstractAllergies are a pervasive issue and require novel ways of alleviating symptoms. Existing treatments are focused on symptom management and immunotherapy, but there is also potential to target the molecules involved in the downstream pathway, particularly the PLCĪ³ enzymatic pathway. Our research aimed to identify important target molecules involved in this pathway that result in the degranulation of mast cells. We intended to inhibit these molecules in order to hinder mast cell degranulation and therefore prevent allergic symptoms. Our results were tested and measured in MC/9 (mouse mast cell) and RBL-2H3 (rat basophilic) cell lines with multiple cell degranulation assays such as the beta-hexosaminidase and tryptase assay. The results were evaluated based on the comparative effect as well as specificity of inhibitors on mast cell degranulation. We aim to find the most ideal inhibitor for the PLCĪ³, SK, S1P2 enzymatic pathways in the signalling cascade in order to most effectively reduce degranulation and thus reduce the allergic response.en_US
dc.description.sponsorshipMosser Lab, Gemstone Honors Program, and our generous LaunchUMD donorsen_US
dc.identifierhttps://doi.org/10.13016/vb24-yeaf
dc.identifier.urihttp://hdl.handle.net/1903/25847
dc.language.isoen_USen_US
dc.relation.isAvailableAtMaryland Center for Undergraduate Research
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.subjectCellular Biology and Molecular Geneticsen_US
dc.subjectCMNSen_US
dc.subjectTeam Cascadeen_US
dc.subjectGemstoneen_US
dc.subjectAllergyen_US
dc.subjectCell Signalingen_US
dc.titleInhibiting Degranulation in Immune Cell Signaling Pathwaysen_US
dc.typePresentationen_US

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