Evaluating Physicochemical Properties of Poly-vinyl Pyrrolidone (PVP) Hydrogels for Local Delivery of Lipoproteins in Glioblastoma Multiforme (GBM)

dc.contributor.advisorAl-Sheikhly, Mohamad
dc.contributor.authorLiu, Cindy
dc.contributor.authorEvensen, Ella
dc.contributor.authorPatel, Aashka
dc.contributor.authorThales-Mogo, Nandi
dc.contributor.authorAsfaw, Deborah
dc.contributor.authorBui, Julia
dc.contributor.authorDeslouches, Jakobi
dc.contributor.authorLee, Isaiah
dc.contributor.authorKapoor, Ria
dc.date.accessioned2024-03-12T15:41:47Z
dc.date.available2024-03-12T15:41:47Z
dc.date.issued2023
dc.description.abstractGlioblastoma multiforme (GBM) is a fast growing, malignant tumor that develops from the glial cells that support the health of the nerve cells that affect the brain and spine. GBM has a low survival rate with minimal drugs/treatment options available. The purpose of our research was to seek potential innovative solutions to the challenges surrounding the treatment of GBM; particularly, we were interested in exploring a novel drug-delivery treatment that could be used in future GBM therapy. Through the use of Poly-vinyl Pyrrolidone (PVP), we aimed to develop a hydrogel with specific biomechanical properties that would contain lipoprotein-encased chemotherapeutic drugs; the idea being that these hydrogels would provide an ideal sustained released over a set amount of time. Using varying polymer concentration, molecular weights, and radiation doses, we tested the physical and chemical properties while simultaneously testing the kinetics of release of lipoproteins in each hydrogel.
dc.identifierhttps://doi.org/10.13016/cwlg-e1nd
dc.identifier.urihttp://hdl.handle.net/1903/32364
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectGemstone Team NANO
dc.titleEvaluating Physicochemical Properties of Poly-vinyl Pyrrolidone (PVP) Hydrogels for Local Delivery of Lipoproteins in Glioblastoma Multiforme (GBM)
dc.typeThesis
local.equitableAccessSubmissionNo

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