Herbal Dietary Supplements: Safety, Efficacy, and Use by Breast Cancer Survivors
Herbal Dietary Supplements: Safety, Efficacy, and Use by Breast Cancer Survivors
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Date
2010
Authors
Frechette, Peter
Galanie, Stephanie
Hung, Anna
Kim, Sarah
Merrick, Kelsey
Nataraj, Krupa
Nooralian, Jessica
Patel, Mihir
Stevens, Jessica
Wang, Vivian
Advisor
Kantor, Mark K.
Citation
DRUM DOI
Abstract
Herbal dietary supplements (HDS) are widely used in complementary,
alternative, and integrative medicine, but data on attitudes, behavior, safety, and
efficacy are lacking. Using mixed methods, we administered an online survey to
>1,000 breast cancer survivors to investigate HDS practices and perceptions and
performed in vitro studies assessing the efficacy and toxicity of actein, a bioactive
component of the HDS black cohosh (Actaea racemosa). Among cancer survivors,
curcumin, flaxseed, and green tea were reported as the most frequently used HDS.
Many subjects increased HDS intake after diagnosis and sought web-based
information on HDS. In human breast cancer (MCF-7) and liver (HepG2/C3A) cell
lines, actein had anti-proliferative and anti-estrogenic effects and did not exhibit
hepatotoxicity or affect the action of tamoxifen and raloxifene.
Notes
Gemstone Team IMAC (Integrative Medicine and Cancer)