Effects of cytoskeletal protein disruption on the deformation of MSCs during chondrogenesis

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dc.contributor.advisorHsieh, Adam Hen_US
dc.contributor.authorVigfusdottir, Agusta Thuriduren_US
dc.contributor.departmentBioengineeringen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2007-06-22T05:37:36Z
dc.date.available2007-06-22T05:37:36Z
dc.date.issued2007-05-07
dc.description.abstractIntervertebral disc degeneration has been identified as a main cause for low back pain, a large health problem in the Western world today with 60%-80% of people affected at some point during their lives. Current treatments alleviate the symptoms rather than repair the tissue, but tissue engineering the intervertebral discs to stem degeneration or to repair damaged tissues may be a realistic alternative. Adult bone marrow derived mesenchymal stem cells are undifferentiated, multipotent cells that have the ability to differentiate into the chondrocyte-like cells found within the nucleus pulposus of the adult intervertebral disc. This study examines one determinant of the cellular mechanotransduction pathway, an important aspect of cell-based therapies. Specifically, we investigate the role of cytoskeletal proteins on resisting mesenchymal stem cell deformation. An improved understanding of the relative contributions of microfilaments and microtubules to cell deformation characteristics will aid in the interpretation of cellular mechanotransduction mechanisms in future studies.en_US
dc.format.extent496636 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/6928
dc.language.isoen_US
dc.subject.pqcontrolledEngineering, Biomedicalen_US
dc.subject.pquncontrolledMSCen_US
dc.subject.pquncontrolledchondrogenesisen_US
dc.subject.pquncontrolledcytochalasin Den_US
dc.subject.pquncontrolledcolchicineen_US
dc.subject.pquncontrolleddeformationen_US
dc.titleEffects of cytoskeletal protein disruption on the deformation of MSCs during chondrogenesisen_US
dc.typeThesisen_US

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