INFLUENCE OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING

Abstract

Title of Thesis : INFLUENCE OF LIPOPROTEIN LIPIDS AND APOLIPOPROTEIN E GENE POLYMORPHISMS ON COAGULATION FACTOR VIII CHANGES WITH SIX MONTHS OF AEROBIC EXERCISE TRAINING. Rakesh Gopinathannair, Master of Arts, 2004. Thesis directed by: Professor James M. Hagberg, Ph.D., Dept. of Kinesiology Elevated plasma factor VIII antigen (FVIII:Ag) level is an independent risk factor for coronary artery disease. Aerobic training improves cardiovascular risk and improvement in coagulation profile might be a potential contributory mechanism. Available evidence suggests that plasma lipoprotein-lipid levels and lipid-related genotypes might have a regulatory effect on plasma FVIII:Ag levels. We assessed the effects of APO E gene polymorphisms and plasma lipoprotein-lipid changes on plasma FVIII:Ag changes with 6 mo of standardized aerobic training in 44 sedentary, 50-75 year old men and women with different APO E genotypes. Plasma FVIII:Ag levels, lipoprotein-lipid levels, VO2 max, and intra-abdominal fat (CTIA) were estimated before and after 6 mo of training . Plasma FVIII:Ag levels showed an increase of 3.5% (152.5±6.7% to 156.0±6.1%, P=0.290) with exercise training. FVIII:Ag levels were positively correlated to CTIA at baseline (r= 0.30) and after training (r=0.37). There was no significant association between FVIII:Ag levels and APO E genotype, before and after covarying for training-induced changes in plasma lipoprotein-lipids. In conclusion, the effect of regular aerobic exercise training on plasma FVIII:Ag levels appears small and clinically insignificant when compared to the clear and beneficial effects on lipoprotein-lipid profile and body composition. Truncal obesity may be a significant factor modulating baseline plasma FVIII:Ag levels and their response to training.