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Method for Identifying Splice Sites and Translational Start Sites in Eukaryotic mRNA

dc.contributor.authorSalzberg, Steven L.
dc.date.accessioned2008-06-18T13:26:54Z
dc.date.available2008-06-18T13:26:54Z
dc.date.issued1997
dc.identifier.citationA Method for Identifying Splice Sites and Translational Start Sites in Eukaryotic mRNA. S.L. Salzberg. Computer Applications in the Biosciences (CABIOS) 13:4 (1997), 365-376.en
dc.identifier.urihttp://hdl.handle.net/1903/8005
dc.description.abstractThis paper describes a new method for determining the consensus sequences that signal the start of donor translation and the boundaries between exons and introns (donor and acceptor sites) in eukaryotic mRNA. The method takes into account the dependencies between adjacent bases, in contrast to the usual technique of considering each position independently. When coupled with a dynamic program to compute the most likely sequence, new consensus sequences emerge. The consensus sequence information is summarized in conditional probability matrices which, when used to locate signals in uncharacterized genomic DNA, have greater sensitivity and specificity than conventional matrices. Species-specific versions of these matrices are especially effective at distinguishing true and false sites.en
dc.format.extent201438 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.publisherComputer Applications in the Biosciences (CABIOS)en
dc.subjectexonsen
dc.subjectintronsen
dc.subjecteukaryotic mRNAen
dc.subjectDNAen
dc.subjectconsensus sequencesen
dc.titleMethod for Identifying Splice Sites and Translational Start Sites in Eukaryotic mRNAen
dc.typeArticleen
dc.relation.isAvailableAtCollege of Computer, Mathematical & Physical Sciencesen_us
dc.relation.isAvailableAtComputer Scienceen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us


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