Fischell Department of Bioengineering Theses and Dissertations
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http://hdl.handle.net/1903/6628
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Recent Submissions
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The effects of mechanical confinement on cancer cell growth and migration mechanisms
(2021)Cancer is a disease in which cell growth proceeds unchecked and cells accumulate mutations to adopt an invasive and migratory phenotype that promotes metastasis. Once a cancer becomes metastatic, survival rates plummet, ... -
Mechanical Adaptability of Ovarian Cancer Tumor Spheroids
(2021)A major obstacle in ovarian cancer treatment is the onset of ascites, an abnormal build-up of fluid in the peritoneal cavity. Using in vitro perfusion models, ascitic flow has been shown to drive epithelial-mesenchymal-transition ... -
Formulation and Delivery of Enhanced Extracellular Vesicles for Wound Repair
(2021)Despite the development of a variety of therapies, complex wounds resulting from disease, surgical intervention, or trauma remain a major source of morbidity. Extracellular vesicles (EVs) have recently emerged as an ... -
A NANOCOMPOSITE HYDROGEL FOR STROMAL CELL-DERIVED FACTOR-1 ALPHA DELIVERY AND MODULATION OF MACROPHAGE PHENOTYPE FOR SKIN TISSUE REGENERATION
(2021)Chronic, non-healing skin wounds arising as a sequela of underlying disease are often difficult to treat clinically, susceptible to infection, and may severely reduce a patient’s quality of life. Tissue engineered constructs ... -
Harnessing self-assembly for modular control of toll-like receptor signaling
(2021)While vaccines have been transformative in stopping – and even eradicating – some pathogens, key hurdles face vaccines for many existing and emerging pathogens. The initiation of immune response requires specialized cells ...