Novel Control Strategies for Catabolite Repressible Fermentations.
Minderman, Peter A.
Gasner, Larry L.
McAvoy, Thomas J.
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Because of the problem of catabolite repression, a sign)ficant class of industrially important fermentations, e.g. enzyme and antibiotic production, are controlled by the fed-batch policy in which the catabolite concentration is maintained at a low, constant, and acceptable level. An improved policy, the pulsed batch policy, is proposed which takes advantage of the sign)ficantly accelerated production rates observed when a microorganism adapts from one environment to another. Experimental and modeling results are presented for the ,BETA galactosidase from Escherichia coli case.