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Mathematical and Molecular Studies of Feline Erythro- and Lymphopoiesis

dc.contributor.advisorSong, Wenxiaen_US
dc.contributor.advisorPontzer, Carol Men_US
dc.contributor.authorEwen, Bren Sen_US
dc.description.abstractFeline leukemia virus, strain KT, is a retrovirus that causes a fatal erythroid aplasia. The fatal loss of erythrocytes is due to the interaction of this virus with the BFU-E stage of feline erythropoietic development. This virus is comparable to the human HTLV retrovirus. Through the development of a computer mathematical model, we demonstrate the disease process and show that infection of the BFU-E leads to a characteristic fatal erythroid aplasia in cats. Fetal feline lymphohematopoietic stem cells, before a certain point in gestation, lack genotypically unique class I major histocompatibility cell-surface antigens (FLA). The elucidation of a gestational time point when FLA appear on the surface of cells within the fetal liver will provide knowledge of when hematopoietic stem cells may be at maximal utility for gene therapy of feline hematopoietic disease, specifically FIV. Here we show that this time point occurs around day 40 in fetal feline gestation.en_US
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dc.titleMathematical and Molecular Studies of Feline Erythro- and Lymphopoiesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentMolecular and Cell Biologyen_US
dc.subject.pqcontrolledBiology, Molecularen_US
dc.subject.pqcontrolledHealth Sciences, Immunologyen_US
dc.subject.pquncontrolledhematopoietic stem cellsen_US
dc.subject.pquncontrolledmathematical modelingen_US
dc.subject.pquncontrolledFeline Leukemia Virusen_US

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