Emotion-regulation strategies are attempts to impact emotions within oneself or others (McRae & Gross, 2020). Strategies such as mindfulness and reappraisal are associated with benefits to well-being and mental health. However, the influence of culture on mindfulness and reappraisal has not been established. Emotion-regulation strategies are culturally dependent. It is through cultural socialization that cultural values are transmitted. Cultural values give meaning to emotion and emotion-regulation strategies. This dissertation proposes a theoretical model in which (1) cultural values predict mindfulness and reappraisal emotion-regulation strategies, and (2) the effectiveness of both strategies is assessed using the emotional dimensions of valence, arousal, power, and surprise. Three pilot studies were conducted to test the validity of emotion-regulation instructional messaging, to create a negatively valenced emotion-eliciting video stimulus, and to assess the differences in mindfulness between American and Chinese students. For the main study, American and Chinese students completed an online experiment that tested the effects of emotion-regulation strategies. The findings suggest that emotion-regulation strategies differ both culturally and in their effects, either altering the emotions individuals feel (in the case of the reappraisal strategy) or the experience individuals associate with the emotions they feel (in the case of the mindfulness strategy). This study supports the need for further investigation into the relationship between cultural socialization’s impact on emotion-regulation strategies.