Current estimation of the Earth’s carbon budget contains large uncertainties, with the largest ones in its terrestrial components. With an overarching goal to improve the understanding of carbon budget at regional to global scales, this study aimed to: 1. Develop a grid-based carbon accounting (GCA) model for estimating carbon fluxes from forest disturbance, tested over North Carolina; 2. Develop a consistent timber product output (TPO) record for a globally important timber production region, including seven states in the southeast U.S.; and 3. Further improve the GCA model based on results from objectives 1 and 2, and use it to derive carbon source/sink estimates for all forest land in North Carolina.The results show that several inputs/parameters such as pre-disturbance carbon density, disturbance intensity, allocation of removed carbon among slash and different wood product pools, and forest growth rates could have large impact on carbon estimates. The total emission between 1986 and 2010 from logging over North Carolina was reduced by one third and two thirds, respectively, when remote sensing-based disturbance intensity and biomass data were used to replace parameter values inherited from the original bookkeeping carbon accounting (BCA) model, and was reduced by over 70% when both were used. Use of the TPO data derived in Chapter 3 to partition the removed carbon among slash and different wood product pools resulted in noticeably higher emission estimates than those derived using the partitioning ratios provided by the original BCA model. In addition, without considering legacy effect from wood products harvested before 1986, the emission value derived using the prompt release method was 50% higher than that derived using the delayed release method. This study addresses multiple sources of uncertainties related to the terrestrial carbon budget. The TPO study demonstrated an approach for deriving consistent TPO records for large timber production regions. The GCA model produced state level carbon estimates comparable to those reported by the U.S. Forest Service while providing critical spatial details needed to support carbon management and advance forest-driven climate change mitigation initiatives.