Show simple item record

A deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos

dc.contributor.authorBertke, Michelle M.
dc.contributor.authorDubiak, Kyle M.
dc.contributor.authorCronin, Laura
dc.contributor.authorZeng, Erliang
dc.contributor.authorHuber, Paul W.
dc.date.accessioned2021-06-07T19:17:22Z
dc.date.available2021-06-07T19:17:22Z
dc.date.issued2019-05-17
dc.identifierhttps://doi.org/10.13016/o1qr-dsby
dc.identifier.citationBertke, M.M., Dubiak, K.M., Cronin, L. et al. A deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos. BMC Genomics 20, 386 (2019).en_US
dc.identifier.urihttp://hdl.handle.net/1903/27124
dc.description.abstractAdenovirus protein, Gam1, triggers the proteolytic destruction of the E1 SUMO-activating enzyme. Microinjection of an empirically determined amount of Gam1 mRNA into one-cell Xenopus embryos can reduce SUMOylation activity to undetectable, but nonlethal, levels, enabling an examination of the role of this post-translational modification during early vertebrate development.en_US
dc.description.urihttps://doi.org/10.1186/s12864-019-5773-3
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.subjectSUMOen_US
dc.subjectHeart developmenten_US
dc.subjectNeural tube developmenten_US
dc.subjectCongenital birth defectsen_US
dc.subjectNon-canonical Wnt signalingen_US
dc.subjectPlanar cell polarityen_US
dc.titleA deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryosen_US
dc.typeArticleen_US
dc.relation.isAvailableAtCollege of Computer, Mathematical & Natural Sciencesen_us
dc.relation.isAvailableAtMathematicsen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record