A deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos

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dc.contributor.authorBertke, Michelle M.
dc.contributor.authorDubiak, Kyle M.
dc.contributor.authorCronin, Laura
dc.contributor.authorZeng, Erliang
dc.contributor.authorHuber, Paul W.
dc.date.accessioned2021-06-07T19:17:22Z
dc.date.available2021-06-07T19:17:22Z
dc.date.issued2019-05-17
dc.description.abstractAdenovirus protein, Gam1, triggers the proteolytic destruction of the E1 SUMO-activating enzyme. Microinjection of an empirically determined amount of Gam1 mRNA into one-cell Xenopus embryos can reduce SUMOylation activity to undetectable, but nonlethal, levels, enabling an examination of the role of this post-translational modification during early vertebrate development.en_US
dc.description.urihttps://doi.org/10.1186/s12864-019-5773-3
dc.identifierhttps://doi.org/10.13016/o1qr-dsby
dc.identifier.citationBertke, M.M., Dubiak, K.M., Cronin, L. et al. A deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos. BMC Genomics 20, 386 (2019).en_US
dc.identifier.urihttp://hdl.handle.net/1903/27124
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtCollege of Computer, Mathematical & Natural Sciencesen_us
dc.relation.isAvailableAtMathematicsen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectSUMOen_US
dc.subjectHeart developmenten_US
dc.subjectNeural tube developmenten_US
dc.subjectCongenital birth defectsen_US
dc.subjectNon-canonical Wnt signalingen_US
dc.subjectPlanar cell polarityen_US
dc.titleA deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryosen_US
dc.typeArticleen_US

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