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Localizing Chemotherapeutic Drug Release Through the Use of Polymer-Based Surgical Sealants to Treat Stage III Colorectal Cancer

dc.contributor.advisorKofinas, Peter
dc.contributor.authorAtalla, Anthony
dc.contributor.authorColey, Morgan
dc.contributor.authorHamers, Matthew
dc.contributor.authorKarodeh, Nima
dc.contributor.authorMcGrath, Jennifer
dc.contributor.authorMinahan, Eva
dc.contributor.authorNagler, Matthew
dc.contributor.authorNassar, Yomna
dc.contributor.authorNichols, Alison
dc.contributor.authorSebastian, Ria
dc.contributor.authorTiberino, Matthew
dc.contributor.authorWendeu-Foyet, Kevin
dc.descriptionGemstone Team TUMORen_US
dc.description.abstractCurrent cancer treatments, such as systemic chemotherapy, induce several complications that affect the entire body; localizing chemotherapy to the tumor site has the potential to minimize harmful side effects. Solution blow spinning (SBS) offers the possibility of incorporating chemotherapy drugs into a polymer solution through the use of a compressed airbrush. This would allow for direct deposit of a polymer mat after surgically removing the tumor. Sutures, in combination with polymer sealants, could be used to prevent complications after surgery. This study focuses on stage IIIA colorectal cancer because cancer cells have not spread distantly yet, and treatment typically involves surgery followed by chemotherapy. Three key aims were addressed in this study to assess polymer-drug combinations’ compatibility with SBS, observe drug release patterns, and evaluate the effect of drug incorporation on polymer adhesion to intestinal tissue. Our results suggested that the polymer-drug combination of poly(L-lactide-co-ε-caprolactone) (PLCL) and capecitabine shows promise as an adhesive surgical sealant with a drug release pattern that is complementary to a typical resection healing timeline.en_US
dc.subjectGemstone Team TUMORen_US
dc.titleLocalizing Chemotherapeutic Drug Release Through the Use of Polymer-Based Surgical Sealants to Treat Stage III Colorectal Canceren_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)

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