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Adaptation of A/Mallard/Potsdam/178-4/83 (H2N2) in Japanese quail leads to Replication and Transmission in Chickens

dc.contributor.advisorPerez, Daniel Ren_US
dc.contributor.authorSorrell, Erin Maureenen_US
dc.description.abstractInfluenza is a single stranded, negative-sense RNA virus with a segmented genome that can infect avian and mammalian species. Influenza viruses from the avian reservoir do not seem to replicate efficiently in humans upon direct transmission. Therefore, an intermediate host is involved in generating mutations to create a more transmissible or an avian-human reassortant virus. Quail have been highlighted as a potential reservoir and intermediate host of avian influenza. To assess the potential of quail as an intermediate host, A/Mallard/Postdam/178-4/83, H2N2 was tested to determine if through adaptation in quail a mallard strain can replicate and transmit in quail, as well as other avian species. After six serial passages of lung homogenate a virus arose, which replicated and transmitted directly to contact quail. When chickens were infected with this quail-adapted virus replication and transmission were observed, while no replication was noted in the chickens infected with wild type H2N2 virus.en_US
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dc.titleAdaptation of A/Mallard/Potsdam/178-4/83 (H2N2) in Japanese quail leads to Replication and Transmission in Chickensen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentAnimal Sciencesen_US
dc.subject.pqcontrolledBiology, Molecularen_US
dc.subject.pquncontrolledInfluenza Aen_US

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