Show simple item record

dc.contributor.advisorRoy, Rajarshien_US
dc.contributor.authorMiller, Stephanie Reginaen_US
dc.date.accessioned2019-09-27T05:43:48Z
dc.date.available2019-09-27T05:43:48Z
dc.date.issued2019en_US
dc.identifierhttps://doi.org/10.13016/cucu-avf3
dc.identifier.urihttp://hdl.handle.net/1903/25065
dc.description.abstractThe generation of cortical dynamics in awake mammals is not yet fully understood. However, it is known that neurons leverage distinct organizational schemes to achieve behavior and cognitive function, and that this precise spatiotemporal organization may go awry in illness. In 2003, a form of scale-free synchrony termed “neuronal avalanches” was first observed by Beggs & Plenz in cultured cortical tissue and later confirmed in rodents, nonhuman primates, and humans. In this dissertation, we draw from monkey and rodent studies to demonstrate that neuronal avalanches capture key features of neural population activity and constitute a robust and stable (e.g. self-organized) indicator of balanced excitation and inhibition in cortical networks. We also show for the first time that neuronal avalanches and oscillations co-exist in frontal cortex of nonhuman primates and identify the avalanche temporal shape as a biomarker predicated upon critical systems theory. Finally, we present progress towards characterizing altered avalanche dynamics in a developmental mouse model for schizophrenia using 2-photon calcium imaging in awake animals.en_US
dc.language.isoenen_US
dc.titleSTABILITY AND SCALING OF NEURONAL AVALANCHES AND THEIR RELATIONSHIP TO NEURONAL OSCILLATIONSen_US
dc.typeDissertationen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentBiophysics (BIPH)en_US
dc.subject.pqcontrolledNeurosciencesen_US
dc.subject.pqcontrolledBiophysicsen_US
dc.subject.pqcontrolledPhysicsen_US
dc.subject.pquncontrolledcritical brain dynamicsen_US
dc.subject.pquncontrollednetwork scienceen_US
dc.subject.pquncontrolledneuronal avalanchesen_US
dc.subject.pquncontrolledneuronal oscillationsen_US
dc.subject.pquncontrolledself-organized criticalityen_US
dc.subject.pquncontrolledsystems neuroscienceen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record