Skip to content
University of Maryland LibrariesDigital Repository at the University of Maryland
    • Login
    View Item 
    •   DRUM
    • Theses and Dissertations from UMD
    • UMD Theses and Dissertations
    • View Item
    •   DRUM
    • Theses and Dissertations from UMD
    • UMD Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Effect of ligand binding on the backbone dynamics of linear and circular constructs of SH3 Domain

    Thumbnail
    View/Open
    umi-umd-2116.pdf (3.174Mb)
    No. of downloads: 1044

    Date
    2004-12-08
    Author
    Chhikara, Ishwar Singh
    Advisor
    Fushman, David
    Metadata
    Show full item record
    Abstract
    Peptide backbone cyclization is an important bio-engineering tool that has been widely used to control the stability, structure and biological role of small peptides. Here we have analyzed the effect of ligand binding on the backbone dynamics of a linear and circular construct of N-terminal SH3 domain of the Murine C-Crk adapter protein. We have also determined the residues on the protein surface involved in binding with the ligand by carrying out a series of HSQC titration experiments at different (ligand/protein) concentrations. This is the first time that the interface for the adapter protein Murine c-Crk N-SH3 domain in complex with C3G derived peptide (ligand) in solution has been determined.
    URI
    http://hdl.handle.net/1903/2140
    Collections
    • Chemistry & Biochemistry Theses and Dissertations
    • UMD Theses and Dissertations

    DRUM is brought to you by the University of Maryland Libraries
    University of Maryland, College Park, MD 20742-7011 (301)314-1328.
    Please send us your comments.
    Web Accessibility
     

     

    Browse

    All of DRUMCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister
    Pages
    About DRUMAbout Download Statistics

    DRUM is brought to you by the University of Maryland Libraries
    University of Maryland, College Park, MD 20742-7011 (301)314-1328.
    Please send us your comments.
    Web Accessibility