Skip to content
University of Maryland LibrariesDigital Repository at the University of Maryland
    • Login
    View Item 
    •   DRUM
    • Theses and Dissertations from UMD
    • UMD Theses and Dissertations
    • View Item
    •   DRUM
    • Theses and Dissertations from UMD
    • UMD Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Absorption and metabolism of 3-MCPD 1-monopalmitate in rats

    Thumbnail
    View/Open
    Gao_umd_0117E_18524.pdf (1.495Mb)
    No. of downloads: 237

    Date
    2017
    Author
    Gao, Boyan
    Advisor
    Yu, Liangli (Lucy)
    DRUM DOI
    https://doi.org/10.13016/M26H4CS02
    Metadata
    Show full item record
    Abstract
    Fatty acid esters of 3-monochloropropane 1,2-diol (3-MCPD esters) are a group of potential chemical toxicants. Their toxic effects primarily include nephrotoxicity and hepatotoxicity. To understand the toxic mechanisms of 3-MCPD esters, one of the key points is to advance the understanding of their metabolic mechanisms in vivo. This dissertation investigated 1) the absorption and kinetics of 3-MCPD 1-monopalmitate in rats, 2) the possible metabolites of 3- MCPD 1-monopalmitate after oral administration to rats, and 3) the possible metabolic pathways of 3-MCPD 1-monopalmitate in vivo. The greatest concentration of 3-MCPD 1-monopalmitate in the plasma was 873.72 ng/mL (Cmax) at about 1.67 hours (Tmax) after oral administration. The concentration of 3-MCPD 1-monopalmitate reduced to half after 3.42 hours (t1/2). No 3-MCPD 1-monopalmitate could be detected after 4 hours, which was its mean resident time (MRT). The area under curve (AUC) for 3-MCPD 1-monopalmitate in rat plasma was 1676.15 h.ng/mL, which represented the maximum amount of 3-MCPD 1-monopalmitate absorbed into plasma under the testing conditions. Beside, 39 possible metabolites were tentatively identified in the liver, kidney, testis, brain, plasma and urine samples at 6, 12, 24 and 48 hours after oral administration of 3-MCPD 1-monopalmitate to rats. In addition, five major metabolic pathways of 3-MCPD esters were derivate to evaluate their metabolic conditions in vivo. These results can greatly enhance the understanding about the absorption, distribution and metabolism conditions of 3-MCPD esters in vivo, and promote further research about the biological actions of 3-MCPD esters.
    URI
    http://hdl.handle.net/1903/20324
    Collections
    • Nutrition & Food Science Theses and Dissertations
    • UMD Theses and Dissertations

    DRUM is brought to you by the University of Maryland Libraries
    University of Maryland, College Park, MD 20742-7011 (301)314-1328.
    Please send us your comments.
    Web Accessibility
     

     

    Browse

    All of DRUMCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister
    Pages
    About DRUMAbout Download Statistics

    DRUM is brought to you by the University of Maryland Libraries
    University of Maryland, College Park, MD 20742-7011 (301)314-1328.
    Please send us your comments.
    Web Accessibility