Show simple item record

Pyrethroid pesticide exposure and parental report of learning disability and attention-deficit hyperactivity disorder in U.S. children: NHANES 1999-2002.

dc.contributor.authorQuiros-Alcala, Lesliam
dc.contributor.authorMehta, Suril
dc.contributor.authorEskenazi, Brenda
dc.date.accessioned2016-11-11T11:49:01Z
dc.date.available2016-11-11T11:49:01Z
dc.date.issued2014
dc.identifierhttps://doi.org/10.13016/M2NF9F
dc.identifier.citationQuirós-Alcalá L, Mehta S, Eskenazi B. 2014. Pyrethroid pesticide exposure and parental report of learning disability and attention deficit/hyperactivity disorder in U.S. Children: NHANES 1999–2002. Environ Health Perspect 122:1336–1342; http://dx.doi.org/10.1289/ehp.1308031en_US
dc.identifier.urihttp://hdl.handle.net/1903/18874
dc.description.abstractBackground: Use of pyrethroid insecticides has increased dramatically over the past decade; however, data on their potential health effects, particularly on children, are limited. Objective: We examined the cross-sectional association between postnatal pyrethroid exposure and parental report of learning disability (LD) and attention deficit/hyperactivity disorder (ADHD) in children 6–15 years of age. Methods: Using logistic regression, we estimated associations of urinary metabolites of pyrethroid insecticides with parent-reported LD, ADHD, and both LD and ADHD in 1,659–1,680 children participating in the National Health and Nutrition Examination Survey (1999–2002). Results: The prevalence rates of parent-reported LD, ADHD, and both LD and ADHD were 12.7%, 10.0%, and 5.4%, respectively. Metabolite detection frequencies for 3-PBA [3-phenoxybenzoic acid], cis-DCCA [cis-(2,2-dichlorovinyl)-2,2-dimethylcyclopr​opane-1-carboxylicacid], and trans-DCCA [trans-(2,2-dichlorovinyl)-2,2-dimethylcyclopr​opane-1-carboxylicacid] were 77.1%, 35.6%, and 33.9%, respectively. The geometric mean 3-PBA concentration was 0.32 μg/L (median = 0.31 μg/L; interquartile rage = 0.10–0.89 μg/L). cis– and trans-DCCA 75th-percentile concentrations were 0.21 μg/L and 0.68 μg/L, respectively. Log10-transformed 3-PBA concentrations were associated with adjusted odds ratios (ORs) of 1.18 (95% CI: 0.92, 1.51) for parent-reported LD, 1.16 (95% CI: 0.85, 1.58) for ADHD, and 1.45 (95% CI: 0.92, 2.27) for both LD and ADHD. Adjusted ORs remained nonsignificant and decreased after controlling for creatinine and other environmental chemicals previously linked to altered neurodevelopment. Similarly, no significant associations were observed for cis– and trans-DCCA. Conclusions: Postnatal pyrethroid exposure was not associated with parental report of LD and/or ADHD. Given the widespread and increasing use of pyrethroids, future research should evaluate exposures at current levels, particularly during critical windows of brain development.en_US
dc.description.sponsorshipThe National Health and Nutrition Examination Survey was conducted by the National Center for Health Statistics, and the data analysis for this research was funded by a Science Innovation Fund from the Passport Foundation. Additional funding was received from the National Institute of Environmental Health Sciences (PO1ES009605) and the U.S. EPA (RD83451301).en_US
dc.language.isoen_USen_US
dc.subjectpyrethroids, neurodevelopment, children, PBA, urine, NHANES, pesticidesen_US
dc.subjectADHD, learning disabilityen_US
dc.titlePyrethroid pesticide exposure and parental report of learning disability and attention-deficit hyperactivity disorder in U.S. children: NHANES 1999-2002.en_US
dc.typeArticleen_US
dc.relation.isAvailableAtSchool of Public Health
dc.relation.isAvailableAtMaryland Institute of Applied Environmental Health
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record