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Investigating the Diabetic Brain: The Effects of Pioglitazone and Insulin on the Cellular Processes and Pathology of Alzheimer's Disease

dc.contributor.advisorDuffy, Kara
dc.contributor.authorBagheri, Tanya
dc.contributor.authorBennett, Vincent
dc.contributor.authorBuck, Annelise
dc.contributor.authorGordge, Kelles
dc.contributor.authorGreen, Ilana
dc.contributor.authorKang, Eric
dc.contributor.authorKim, Nahye
dc.contributor.authorMcCue, Caroline
dc.contributor.authorMehta, Unnati
dc.contributor.authorMorken, Shannon
dc.contributor.authorRezwan, Mayumi
dc.contributor.authorZachery, Ashley
dc.date.accessioned2016-06-10T19:34:49Z
dc.date.available2016-06-10T19:34:49Z
dc.date.issued2016-05
dc.identifierhttps://doi.org/10.13016/M2120N
dc.identifier.urihttp://hdl.handle.net/1903/18088
dc.description.abstractAlzheimer’s disease (AD) is the sixth leading cause of death in the US. Some researchers refer to AD as “Type III Diabetes” because of reported glucose metabolism dysfunction. Preclinical studies suggest increasing insulin decreases AD pathology, although the mechanism remains unclear. To sensitize insulin signaling, this study activated Peroxisome Proliferator-Activated Receptor Gamma using intranasal co-administration of pioglitazone (PGZ) and insulin. This method targeted the site of action to reduce peripheral effects and to maximize impact in transgenic mice expressing AD pathology. Data from GC-MS fluxomics analysis suggested that PGZ+Insulin increased glucose metabolism in the brain. Immunohistochemistry with relevant antibodies was used to identify AD pathological markers in the subiculum, indicating that PGZ+Insulin decreased pathology compared to Insulin and Saline. This suggests that increasing glucose uptake in the brain alleviated AD pathology, further clarifying the role of insulin signaling in AD pathology.Gemstoneen_US
dc.language.isoen_USen_US
dc.subjectGemstone Team Brain Blasten_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectpioglitazoneen_US
dc.subjectinsulinen_US
dc.subjectdiabetes
dc.titleInvestigating the Diabetic Brain: The Effects of Pioglitazone and Insulin on the Cellular Processes and Pathology of Alzheimer's Diseaseen_US
dc.typeThesisen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)


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