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Absorption, Excretion, and Transformation of Individual Anthocyanins in Rats

dc.contributor.advisorGiusti, Monica Men_US
dc.contributor.advisorMagnuson, Bernadene Aen_US
dc.contributor.authorHe, Jianen_US
dc.date.accessioned2004-08-27T05:27:32Z
dc.date.available2004-08-27T05:27:32Z
dc.date.issued2004-08-06en_US
dc.identifier.urihttp://hdl.handle.net/1903/1765
dc.description.abstractAnthocyanins are polyphenolics responsible for most red to purple colors in plants. Human consumption is increasing because of their potential health benefits and use as natural colorants. However, their absorption and metabolism are not well characterized. We compared anthocyanin absorption and excretion in rats receiving chokeberry, bilberry or grape enriched diet (4g anthocyanin/kg) for 13 weeks. Traces of anthocyanins and metabolites were detected in plasma. In urine, intact anthocyanins and methylated derivatives (~ 24, 8, 15 mg cy-3-gla equivalent/L urine for chokeberry, bilberry, grape) were found. High metabolite concentration suggested accumulation of methylated anthocyanins in tissue. Fecal anthocyanin extraction was maximized with aqueous methanol (60%). Anthocyanin concentration in feces ranged from 0.7 to 2g anthocyanin/kg, similar to cecal content. In the gut, anthocyanin degradation was high for glucosides, moderate for galactosides and negligible for arabinosides and xylosides. Both, glycosylation and acylation seemed to affect the bioavailability of anthocyanins in vivo.en_US
dc.format.extent1393460 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.titleAbsorption, Excretion, and Transformation of Individual Anthocyanins in Ratsen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentFood Scienceen_US
dc.subject.pqcontrolledAgriculture, Food Science and Technologyen_US
dc.subject.pqcontrolledHealth Sciences, Nutritionen_US
dc.subject.pqcontrolledChemistry, Analyticalen_US
dc.subject.pquncontrolledanthocyaninen_US
dc.subject.pquncontrolledraten_US
dc.subject.pquncontrolledurineen_US
dc.subject.pquncontrolledfecesen_US
dc.subject.pquncontrolledplasmaen_US
dc.subject.pquncontrolledglycosylationen_US


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