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Exercise training-associated differences in circulating microRNAs and serum-induced endothelial cell migration rate

dc.contributor.advisorHagberg, James Men_US
dc.contributor.authorSapp, Ryan M.en_US
dc.date.accessioned2016-02-09T06:35:10Z
dc.date.available2016-02-09T06:35:10Z
dc.date.issued2015en_US
dc.identifierhttps://doi.org/10.13016/M2HM8J
dc.identifier.urihttp://hdl.handle.net/1903/17373
dc.description.abstractCardiovascular Diseases (CVDs) are the primary source of global mortality and morbidity. The initial steps of CVD development occur in the endothelium. MicroRNAs (miRNAs) have recently emerged as novel regulators of cardiovascular physiology and pathology. Interestingly, regular aerobic exercise acts to prevent CVDs and also regulates miRNAs in the circulation (ci-miRNAs). The purpose of this study was to determine the effects of serum from highly active and sedentary, young, healthy individuals on migration rate of endothelial cells in vitro. Secondarily, CVD-associated ci-miRNAs in serum were compared between groups. The results of this study represent a novel way by which sedentary behavior may act as an early risk for CVD development before the appearance of other classic risk factors. RT-qPCR array analysis identified nine ci-miRNAs as > 4-fold differentially expressed in serum of trained versus inactive subjects, though more subjects are needed before any conclusions about ci-miRNA differences can be made.en_US
dc.language.isoenen_US
dc.titleExercise training-associated differences in circulating microRNAs and serum-induced endothelial cell migration rateen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentKinesiologyen_US
dc.subject.pqcontrolledKinesiologyen_US
dc.subject.pqcontrolledPhysiologyen_US
dc.subject.pquncontrolledCardiovascular Diseaseen_US
dc.subject.pquncontrolledEndothelialen_US
dc.subject.pquncontrolledExerciseen_US
dc.subject.pquncontrolledmicroRNAen_US
dc.subject.pquncontrolledMigrationen_US
dc.subject.pquncontrolledSerumen_US


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