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    INVESTIGATING THE INTERACTIONS BETWEEN BIOPOLYMERS AND BLOOD VIA OPTICAL MICROSCOPY

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    No. of downloads: 15

    Date
    2015
    Author
    MacIntire, Ian Collins
    Advisor
    Raghavan, Srinivasa R
    DRUM DOI
    https://doi.org/10.13016/M2F06Z
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    Abstract
    Hydrophobically modified (hm) derivatives of biopolymers such as chitosan have been shown to convert liquid blood into an elastic gel. This interesting material property could make hm-chitosan (hmC) useful as a hemostatic agent in treating severe bleeding. In this work, we attempted to probe the mechanism of action of hmC by studies on mixtures of blood cells and hmC using optical microscopy. Our results show that the presence of hydrophobic tails on hmC induces significant clustering of blood cells. We show that clustering increases as the fraction of hydrophobic tails on hmC increases, length of the hydrophobic tails increases, and as concentration of hmC increases. Finally, clustering due to hmC could be reversed by the addition of the supramolecule a-cyclodextrin, which is known to capture hydrophobes in its binding pocket. The results from this work support the earlier mechanism, with a few important modifications.
    URI
    http://hdl.handle.net/1903/16944
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    • Chemical and Biomolecular Engineering Theses and Dissertations
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    DRUM is brought to you by the University of Maryland Libraries
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