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The Effects of Insulin-Induced Moderate Hypoglycemia on Hippocampal Plasticity

dc.contributor.advisorGlasper, Erica
dc.contributor.authorFrankel, Joseph
dc.contributor.authorGunther, Kelley
dc.contributor.authorMatthews, Lex
dc.contributor.authorPlakkot, Siddarth
dc.contributor.authorSer, Eileen
dc.contributor.authorShapiro, Melanie
dc.contributor.authorWeng, Peter
dc.contributor.authorWilkin, Danielle
dc.contributor.authorXu, Linhan
dc.description.abstractSelf-regulation of blood glucose in diabetics via insulin administration introduces the risk of hypoglycemia. Previous studies have shown hypoglycemia damages the dentate gyrus, an area of the hippocampus associated with anxiety- and depressive-like behavior. To date, only depressive-like behaviors have been observed following moderate hypoglycemia. This study sought to examine whether acute moderate hypoglycemia induces both behaviors due to high clinical comorbidity. One episode of moderate hypoglycemia was induced in a male Sprague-Dawley rat. Twenty-four hours later, hippocampal function was evaluated via the elevated plus maze and the forced swim test to assess anxiety-like and depressive-like behavior. Results, though not statistically significant, suggested that acute moderate hypoglycemia may increase anxiety- and depressive-like behavior. These findings may elucidate hypoglycemia-related behavioral changes.en_US
dc.subjectbehavioral changesen_US
dc.subjectGemstone Team PANCREASen_US
dc.titleThe Effects of Insulin-Induced Moderate Hypoglycemia on Hippocampal Plasticityen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)

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