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Effects of Gallium-Desferrioxamine Compounds on Bacteria

dc.contributor.advisorWoodard, Ben
dc.contributor.authorAhmed, Mohammad
dc.contributor.authorBrode, Emily
dc.contributor.authorBrown, Thomas
dc.contributor.authorEltoweissy, Somayah
dc.contributor.authorGross, Stephanie
dc.contributor.authorMarkowitz, Seth
dc.contributor.authorMcCutchen, Michael
dc.contributor.authorPortney, Reed
dc.contributor.authorReinhart, Jacob
dc.contributor.authorSalgado, Cristian
dc.contributor.authorWalsh, Melissa
dc.contributor.authorWassel, Sean
dc.date.accessioned2015-07-14T14:39:16Z
dc.date.available2015-07-14T14:39:16Z
dc.date.issued2015
dc.identifierhttps://doi.org/10.13016/M2305G
dc.identifier.urihttp://hdl.handle.net/1903/16761
dc.description.abstractOver 70% of nosocomial infections in the United States are resistant to one or more traditional antibiotics, necessitating research for alternative treatment options. This study aims to chelate gallium (Ga) onto a bacterial siderophore, desferrioxamine (DFO), to retard bacterial growth. By exploiting natural bacterial pathways, metal-siderophore treatments are hypothesized to circumvent traditional resistance mechanisms. Additionally, the GaDFO complex will be tested against several bacterial species to determine the specificity of DFO uptake. This research aims to prove the feasibility of siderophore piracy as an alternative to antibiotics. In showing the feasibility of siderophore piracy mechanisms, this research will enable the development of future avenues for protecting against resistant nosocomial infections.en_US
dc.language.isoen_USen_US
dc.subjectNosocomial Infectionsen_US
dc.subjectBacteriaen_US
dc.subjectGallium Desferrioxamine (GaDFO)en_US
dc.subjectGemstone Team SILVERen_US
dc.titleEffects of Gallium-Desferrioxamine Compounds on Bacteriaen_US
dc.typeThesisen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)


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