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    Effects of Gallium-Desferrioxamine Compounds on Bacteria

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    No. of downloads: 940

    Date
    2015
    Author
    Ahmed, Mohammad
    Brode, Emily
    Brown, Thomas
    Eltoweissy, Somayah
    Gross, Stephanie
    Markowitz, Seth
    McCutchen, Michael
    Portney, Reed
    Reinhart, Jacob
    Salgado, Cristian
    Walsh, Melissa
    Wassel, Sean
    Advisor
    Woodard, Ben
    DRUM DOI
    https://doi.org/10.13016/M2305G
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    Abstract
    Over 70% of nosocomial infections in the United States are resistant to one or more traditional antibiotics, necessitating research for alternative treatment options. This study aims to chelate gallium (Ga) onto a bacterial siderophore, desferrioxamine (DFO), to retard bacterial growth. By exploiting natural bacterial pathways, metal-siderophore treatments are hypothesized to circumvent traditional resistance mechanisms. Additionally, the GaDFO complex will be tested against several bacterial species to determine the specificity of DFO uptake. This research aims to prove the feasibility of siderophore piracy as an alternative to antibiotics. In showing the feasibility of siderophore piracy mechanisms, this research will enable the development of future avenues for protecting against resistant nosocomial infections.
    URI
    http://hdl.handle.net/1903/16761
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    DRUM is brought to you by the University of Maryland Libraries
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