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A TEMPERATURE-CONTROLLED ELECTROCHEMICAL MICROSCALE PLATFORM FOR BIOMOLEMULAR BINDING STUDIES

dc.contributor.advisorSintim, Herman Oen_US
dc.contributor.advisorSemancik, Steveen_US
dc.contributor.authorShen, Zuliangen_US
dc.date.accessioned2015-02-06T06:43:15Z
dc.date.available2015-02-06T06:43:15Z
dc.date.issued2014en_US
dc.identifierhttps://doi.org/10.13016/M2Z61S
dc.identifier.urihttp://hdl.handle.net/1903/16192
dc.description.abstractElectrochemical detection of nucleic acids has been a very important research area in the past several decades. In this research field, the stability of the nucleic acid structure is important and crucial for many aspects of nucleic acid metabolism. Also the binding of small molecule ligands to nucleic acids and resulting increase in stability of the nucleic acids can play a key role in many context including DNA-targeted therapy against various cancers, bacteria or viruses. Melting curve analysis using electrochemical detection, as a new method to characterize nucleic acids' stability and interactions between small molecules, provides high sensitivity and is also well suited for high-throughput formats. This thesis describes efforts to develop melting curve analysis using electrochemical detection method on a temperature-controlled microscale platform.en_US
dc.language.isoenen_US
dc.titleA TEMPERATURE-CONTROLLED ELECTROCHEMICAL MICROSCALE PLATFORM FOR BIOMOLEMULAR BINDING STUDIESen_US
dc.typeDissertationen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentChemistryen_US
dc.subject.pqcontrolledAnalytical chemistryen_US
dc.subject.pquncontrolledBiomolecular binding stabilityen_US
dc.subject.pquncontrolledDNA melting curvesen_US
dc.subject.pquncontrolledDNA self-assemblyen_US
dc.subject.pquncontrolledDNA thermal amplificationen_US
dc.subject.pquncontrolledMicrofabricated electrochemical platformen_US
dc.subject.pquncontrolledRapid temperature controlen_US


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