Skip to content
University of Maryland LibrariesDigital Repository at the University of Maryland
    • Login
    View Item 
    •   DRUM
    • Theses and Dissertations from UMD
    • UMD Theses and Dissertations
    • View Item
    •   DRUM
    • Theses and Dissertations from UMD
    • UMD Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    COMPUTATIONAL STUDIES ON ORGANELLE-SPECIFIC YEAST MEMBRANE MODELS

    Thumbnail
    View/Open
    MonjeGalvan_umd_0117N_15866.pdf (2.842Mb)
    No. of downloads: 251

    Date
    2014
    Author
    Monje-Galvan, Viviana
    Advisor
    Klauda, Jeffery B
    DRUM DOI
    https://doi.org/10.13016/M2M609
    Metadata
    Show full item record
    Abstract
    Computational models were built for the endoplasmic reticulum (ER), trans-Golgi network (TGN), and plasma membranes (PM) of yeast Saccharomyces cerevisiae. Based on experimental data, ergosterol, phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol lipids were included. Lipid packing, order parameters (SCD), electron density profiles (EDPs), and lipid rotation were studied for each model. The average surface area per lipid decreased from 63.82±0.03 Å2 in the ER to 47.09±0.12 Å2 at the PM; while the compressibility modulus (KA) varied in opposite direction (PM>TGN>ER). The SCD values were higher (more ordered) for the PM lipids than the ER and TGN membranes by a factor of 1.5. The bilayer thickness estimated from EDPs was larger for the PM (43.9±0.1 Å) than the ER or TGN (37.6±0.1 Å). These properties followed expected experimental trends and were compared against a previous model built by Jo et al. (Biophys J. 2009, 97:50-58).
    URI
    http://hdl.handle.net/1903/16125
    Collections
    • Chemical and Biomolecular Engineering Theses and Dissertations
    • UMD Theses and Dissertations

    DRUM is brought to you by the University of Maryland Libraries
    University of Maryland, College Park, MD 20742-7011 (301)314-1328.
    Please send us your comments.
    Web Accessibility
     

     

    Browse

    All of DRUMCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister
    Pages
    About DRUMAbout Download Statistics

    DRUM is brought to you by the University of Maryland Libraries
    University of Maryland, College Park, MD 20742-7011 (301)314-1328.
    Please send us your comments.
    Web Accessibility