Show simple item record

PRINCIPLES FOR NEW OPTICAL TECHNIQUES IN MEDICAL DIAGNOSTICS FOR mHEALTH APPLICATIONS

dc.contributor.advisorBruck, Hugh Aen_US
dc.contributor.authorBalsam, Joshuaen_US
dc.date.accessioned2014-06-26T05:38:18Z
dc.date.available2014-06-26T05:38:18Z
dc.date.issued2014en_US
dc.identifier.urihttp://hdl.handle.net/1903/15463
dc.description.abstractMedical diagnostics is a critical element of effective medical treatment. However, many modern and emerging diagnostic technologies are not affordable or compatible with the needs and conditions found in low-income and middle-income countries and regions. Resource-poor areas require low-cost, robust, easy-to-use, and portable diagnostics devices compatible with telemedicine (i.e. mHealth) that can be adapted to meet diverse medical needs. Many suitable devices will need to be based on optical technologies, which are used for many types of biological analyses. This dissertation describes the fabrication and detection principles for several low-cost optical technologies for mHealth applications including: (1) a webcam based multi-wavelength fluorescence plate reader, (2) a lens-free optical detector used for the detection of Botulinum A neurotoxin activity, (3) a low cost micro-array reader that allows the performance of typical fluorescence based assays demonstrated for the detection of the toxin staphylococcal enterotoxin (SEB), and (4) a wide-field flow cytometer for high throughput detection of fluorescently labeled rare cells. This dissertation discusses how these technologies can be harnessed using readily available consumer electronics components such as webcams, cell phones, CCD cameras, LEDs, and laser diodes. There are challenges in developing devices with sufficient sensitivity and specificity, and approaches are presented to overcoming these challenges to create optical detectors that can serve as low cost medical diagnostics in resource-poor settings for mHealth.en_US
dc.language.isoenen_US
dc.titlePRINCIPLES FOR NEW OPTICAL TECHNIQUES IN MEDICAL DIAGNOSTICS FOR mHEALTH APPLICATIONSen_US
dc.typeDissertationen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentMechanical Engineeringen_US
dc.subject.pqcontrolledMechanical engineeringen_US
dc.subject.pqcontrolledHealth sciencesen_US
dc.subject.pqcontrolledOpticsen_US
dc.subject.pquncontrolledflow cytometryen_US
dc.subject.pquncontrolledglobal healthen_US
dc.subject.pquncontrolledLOCen_US
dc.subject.pquncontrolledmHealthen_US
dc.subject.pquncontrolledPOCen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record