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Identification and characterization of long intergenic noncoding RNAs associated with Marek's disease resistance in chicken

dc.contributor.advisorSong, Jiuzhouen_US
dc.contributor.authorZhan, Feien_US
dc.date.accessioned2014-02-04T06:31:24Z
dc.date.available2014-02-04T06:31:24Z
dc.date.issued2013en_US
dc.identifier.urihttp://hdl.handle.net/1903/14775
dc.description.abstractMarek's disease (MD) is a highly contagious lymphomatous disease of chicken caused by Marek's disease virus (MDV). MDV has steadily evolved toward increased resistance and virulence over the past decades. A promising strategy for MD prevention and control would be the enhancement of genetic resistance. This study aimed to investigate the roles of long intergenic noncoding RNAs (lincRNAs) in MD resistance and susceptibility in chickens. We reported more than 1000 lincRNA loci in chicken. Computational functional annotation suggested that lincRNAs were involved in a wide range of biological processes. Moreover, distinct lincRNA expression signatures were observed between MD resistance and susceptible chickens. Additionally, a candidate lincRNA termed linc-stab1 was identified and it may play an important role in MD immune response by regulating a nearby protein-coding gene STAB1. In summary, our results demonstrated that lincRNAs also play an important role in MD resistance and provide good candidates for hypothesis-driven functional studies.en_US
dc.language.isoenen_US
dc.titleIdentification and characterization of long intergenic noncoding RNAs associated with Marek's disease resistance in chickenen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentAnimal Sciencesen_US
dc.subject.pqcontrolledBioinformaticsen_US
dc.subject.pqcontrolledAnimal sciencesen_US
dc.subject.pqcontrolledAnimal diseasesen_US
dc.subject.pquncontrolledlincRNAen_US
dc.subject.pquncontrolledlong intergenic noncoding RNAsen_US
dc.subject.pquncontrolledlong noncoding RNAen_US
dc.subject.pquncontrolledMarek's diseaseen_US
dc.subject.pquncontrollednoncoding RNAen_US


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