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NETWORK OPTIMIZATION IN THE BRAIN [I, 1991]: From C. elegans to Cerebral Cortex

dc.contributor.authorCherniak, Christopheren_US
dc.date.accessioned2004-05-31T23:32:06Z
dc.date.available2004-05-31T23:32:06Z
dc.date.created2003-09en_US
dc.date.issued2003-09-25en_US
dc.identifier.urihttp://hdl.handle.net/1903/1310
dc.description.abstractHow well do "Save wire" concepts from combinatorial network optimization theory fit as models for brain anatomy? One result concerns ganglion placement in the nervous system of C. elegans: Our exhaustive searches indicate that the actual layout of the ganglia in the roundworm requires less total interconnecting wirelength than any of the 40 million other possible layouts -- a predictive success story. For the corresponding, but combinatorially intractable, question of interconnection wire- minimization in placement of the areas on the cerebral cortex sheet, we tested instead an "Adjacency Rule": If components a and b are interconnected, then they are contiguous. If cortical components are placed to minimize total interconnection costs, one would expect conformation to this rule; we found strong support for both macaque and cat visual cortex, as well as C. elegans ganglia. [ MH49867 9/91 3.0 ] (UMIACS-TR-2003-92)en_US
dc.format.extent1509903 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.relation.ispartofseriesUM Computer Science Department; CS-TR-4524en_US
dc.relation.ispartofseriesUMIACS; UMIACS-TR-2003-92en_US
dc.titleNETWORK OPTIMIZATION IN THE BRAIN [I, 1991]: From C. elegans to Cerebral Cortexen_US
dc.typeTechnical Reporten_US
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_US
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md.)en_US
dc.relation.isAvailableAtTech Reports in Computer Science and Engineeringen_US
dc.relation.isAvailableAtUMIACS Technical Reportsen_US


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