Fusarium head blight (FHB) is a devastating fungal disease affecting Triticum aestivum crops worldwide. While many quantitative trait loci (QTL) responsible for FHB resistance have been reported, some widely used sources are from exotic cultivars that may carry undesirable alleles linked with resistance. Ning_7840, a Chinese hard red spring wheat, contains a major FHB QTL on the 3BS chromosome, along with two minor QTL on the 5A and 2DL chromosomes. Ning_7840 was crossed with Pioneer_2643, a soft red winter wheat, to create 86 recombinant inbred lines. The effect of the Ning_7840 alleles on agronomic traits and milling and baking quality traits was examined over three growing seasons in Maryland. While the 3BS QTL was not associated negatively with other traits, the 2DL and 5A QTL were. This suggests the introduction of FHB resistance QTL on 5A and 2DL into soft red winter wheat may negatively affect agronomic and quality traits.