The article discusses how the creation of PubChem, the introduction of DiscoveryGate, and the emergence of Chemistry Central are changing the field of chemical information. PubChem is a free service that was launched by the U.S. National Institutes of Health (NIH) in 2004 to provide information on small organic molecules. DiscoveryGate boasts the largest collection of chemical properties. The collaboration between a free (PubChem) and a proprietary service (DiscoveryGate) is a new model for providing scientific information. Chemistry Central is an open-access scientific publisher in the United Kingdom.