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    AUTOMATION MODEL FOR pH AND CONDUCTIVITY ADJUSTMENT FOR A CATION EXCHANGE COLUMN ELUATE BUFFER

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    Date
    2010
    Author
    Parmar, Anupreet
    Advisor
    Bentley, William E
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    Abstract
    A comprehensive model for calculating pH and conductivity values for a buffer solution added to the eluate of a cation exchange column at Bayer Healthcare has been developed. Bayer Healthcare's Berkeley facility manufacturess Kogenate - a drug for Hemophilia. This project was carried out at one of the intermediate purification steps of Kogenate, where the pH and conductivity of a buffer solution added to a chromatographic column's eluate has to be critically adjusted. Currently this process is done manually and requires two operators. In order to reduce the manual labor as well as improve accuracy, an automation model was developed using feedback control and Bayer's pH and conductivity predicting empirical correlations.
    URI
    http://hdl.handle.net/1903/10475
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    • Chemical and Biomolecular Engineering Theses and Dissertations
    • UMD Theses and Dissertations

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    DRUM is brought to you by the University of Maryland Libraries
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