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Herbal Dietary Supplements: Safety, Efficacy, and Use by Breast Cancer Survivors

dc.contributor.advisorKantor, Mark K.
dc.contributor.authorFrechette, Peter
dc.contributor.authorGalanie, Stephanie
dc.contributor.authorHung, Anna
dc.contributor.authorKim, Sarah
dc.contributor.authorMerrick, Kelsey
dc.contributor.authorNataraj, Krupa
dc.contributor.authorNooralian, Jessica
dc.contributor.authorPatel, Mihir
dc.contributor.authorStevens, Jessica
dc.contributor.authorWang, Vivian
dc.contributor.authorZhou, Albert
dc.descriptionGemstone Team IMAC (Integrative Medicine and Cancer)
dc.description.abstractHerbal dietary supplements (HDS) are widely used in complementary, alternative, and integrative medicine, but data on attitudes, behavior, safety, and efficacy are lacking. Using mixed methods, we administered an online survey to >1,000 breast cancer survivors to investigate HDS practices and perceptions and performed in vitro studies assessing the efficacy and toxicity of actein, a bioactive component of the HDS black cohosh (Actaea racemosa). Among cancer survivors, curcumin, flaxseed, and green tea were reported as the most frequently used HDS. Many subjects increased HDS intake after diagnosis and sought web-based information on HDS. In human breast cancer (MCF-7) and liver (HepG2/C3A) cell lines, actein had anti-proliferative and anti-estrogenic effects and did not exhibit hepatotoxicity or affect the action of tamoxifen and raloxifene.en_US
dc.subjectHerbal dietary supplementsen_US
dc.subjectBreast canceren_US
dc.subjectGemstone Team IMAC (Integrative Medicine and Cancer)
dc.titleHerbal Dietary Supplements: Safety, Efficacy, and Use by Breast Cancer Survivorsen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)

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