A. James Clark School of Engineering

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Author: search.filters.author.Koolivand, Abdollah

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    Effect of a Cationic Surfactant on Microemulsion Globules and Drug Release from Hydrogel Contact Lenses
    (MDPI, 2019-06-06) Torres-Luna, Cesar; Hu, Naiping; Koolivand, Abdollah; Fan, Xin; Zhu, Yuli; Domszy, Roman; Yang, Jeff; Yang, Arthur; Wang, Nam Sun
    The present study evaluates the in vitro release of diclofenac sodium (DFNa) from contact lenses based on poly-2-hydroxyethyl methacrylate (pHEMA) hydrogels containing an embedded microemulsion to extend release duration. The oil (ethyl butyrate)-in-water microemulsion systems are prepared with two non-ionic surfactants, Brij 97 or Tween 80, together with a long-alkyl chain cationic surfactant, cetalkonium chloride (CKC). Without CKC, Brij 97 or Tween 80-based microemulsions showed average droplet sizes of 12 nm and 18 nm, respectively. The addition of CKC decreased the average droplet sizes to 2–5 nm for both non-ionic surfactants. Such significant reduction in the average droplet size corresponds to an increase in the DFNa release duration as revealed by the in vitro experiments. Contact lens characterization showed that important properties such as optical transparency and water content of Brij 97-based contact lenses with cationic microemulsions was excellent. However, the optical transparency of the corresponding Tween 80 based contact lenses was unsatisfactory. The results indicate that cationic microemulsion-laden contact lenses can benefit from combinatory effects of microemulsions and cationic surfactant at low CKC weight percentage, e.g., with the release of 70% of the drug in 45, 10, and 7 h for B97-CKC-0.45%, CKC-0.45%, and control lenses, respectively. However, the microemulsion effect on extending DFNa release became negligible at the highest CKC weight percentage (1.8%).
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    Formation of Drug-Participating Catanionic Aggregates for Extended Delivery of Non-Steroidal Anti-Inflammatory Drugs from Contact Lenses
    (MDPI, 2019-10-10) Torres-Luna, Cesar; Koolivand, Abdollah; Fan, Xin; Agrawal, Niti R.; Hu, Naiping; Zhu, Yuli; Domszy, Roman; Briber, Robert M.; Wang, Nam Sun; Yang, Arthur
    This paper focuses on extending drug release duration from contact lenses by incorporating catanionic aggregates. The aggregates consist of a long-chain cationic surfactant, i.e., cetalkonium chloride (CKC), and an oppositely charged anti-inflammatory amphiphilic drug. We studied three non-steroidal anti-inflammatory (NSAID) drugs with different octanol–water partition coefficients; diclofenac sodium (DFNa), flurbiprofen sodium (FBNa), and naproxen sodium (NPNa). Confirmation of catanionic aggregate formation in solution was determined by steady and dynamic shear rheology measurements. We observed the increased viscosity, shear thinning, and viscoelastic behavior characteristic of wormlike micelles; the rheological data are reasonably well described using a Maxwellian fluid model with a single relaxation time. In vitro release experiments demonstrated that the extension in the drug release time is dependent on the ability of a drug to form viscoelastic catanionic aggregates. Such aggregates retard the diffusive transport of drug molecules from the contact lenses. Our study revealed that the release kinetics depends on the CKC concentration and the alkyl chain length of the cationic surfactant. We demonstrated that more hydrophobic drugs such as diclofenac sodium show a more extended release than less hydrophobic drugs such as naproxen sodium.
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    Motion of an Elastic Capsule in a Trapezoidal Microchannel under Stokes Flow Conditions
    (MDPI, 2020-05-17) Koolivand, Abdollah; Dimitrakopoulos, Panagiotis
    Even though the research interest in the last decades has been mainly focused on the capsule dynamics in cylindrical or rectangular ducts, channels with asymmetric cross-sections may also be desirable especially for capsule migration and sorting. Therefore, in the present study we investigate computationally the motion of an elastic spherical capsule in an isosceles trapezoidal microchannel at low and moderate flow rates under the Stokes regime. The steady-state capsule location is quite close to the location where the single-phase velocity of the surrounding fluid is maximized. Owing to the asymmetry of the trapezoidal channel, the capsule’s steady-state shape is asymmetric while its membrane slowly tank-treads. In addition, our investigation reveals that tall trapezoidal channels with low base ratios produce significant off-center migration for large capsules compared to that for smaller capsules for a given channel length. Thus, we propose a microdevice for the sorting of artificial and physiological capsules based on their size, by utilizing tall trapezoidal microchannels with low base ratios. The proposed sorting microdevice can be readily produced via glass fabrication or as a microfluidic device via micromilling, while the required flow conditions do not cause membrane rupture.
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    DYNAMICS OF CAPSULES IN COMPLEX MICROFLUIDIC DEVICES
    (2018) Koolivand, Abdollah; Dimitrakopoulos, Panagiotis; Chemical Engineering; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    The dynamics of micro-capsules has attracted a lot of attention in the last decade due to their vast applications in different industrial sectors such as cosmetic products, food industry, chemical processes, reaction systems, cell modeling, drug delivery, and medical processes. Additionally, biological cells such as red blood cells can be modeled as capsules. Understanding the rheological behavior of these cells provides great physical insight for early diagnosis of relevant diseases. The main objective of this research is to investigate the effects of physical and geometrical parameters on the hydrodynamics of simple and multiple capsules in complex mi- crofluidic devices. For this purpose, we have developed the mathematical formulation needed for modeling multiple capsules with or without complex internal structures. The developed framework provides an enormous flexibility in problem definition, and facilitates the investigation of the hydrodynamics of a wide class of capsules in microfluidic channels and vascular capillaries. We first study the deformation of a spherical capsule in a T-junction channel. It is shown that an initially spherical capsule develops a bean shape at low flow rates and an inverse kayak shape at high flow rates. Based on the non-trivial deformation of the capsule, a new methodology for the determination of membrane moduli is proposed. For an accurate determination of the membrane moduli, it is paramount to measure the capsule dimensions precisely, which is easier in the proposed device owning to the stagnation-point flow of the T-junction. To determine the membrane moduli, one needs to do a single experiment for different flow rates, and compare the experimental measurements of the capsule steady-state dimensions with the provided computational data. We then consider the flow dynamics of non-spherical capsules and investi- gate the effects spheroidity and initial orientation on the steady-state shape. It is found that a non-spherical capsule, placed with a non-zero initial orientation angle along the centerline of a microchannel, does not practically rotate during deforma- tion. Thus, precise instrumentation is required for proper alignment of the capsule which influences the deformation and steady-state shape. This behavior may explain possible inconsistencies between measured (experimental) and calculated (compu- tational) shapes. We then study the lateral migration of capsules with different size in a mi- crofluidic channel with a trapezoidal cross-section. Owing to the emergence of 3D printing technology, fabrication of a channel with trapezoidal cross-section is fea- sible. Based on our computational data, we proposed an optimized geometry that could be utilized for separation of capsules or cells with different size. The main advantage of the proposed geometry is its inexpensive fabrication cost without the need for incorporating complicated inner structures, which automatically eliminates the risk of channel clogging. Moreover, the simple structure of the trapezoidal mi- crochannel allows an easy scale out through parallelization and reduction of the cell sorting time. In addition, we investigate the complex behavior of two (equal or unequal sized) capsules flowing in a square microfluidic channel. Capsules merging process controls the on-demand drug release and reaction. Thus, we identified the hydro- dynamic conditions that facilitates or hinders the merging of the capsules. The merging process is commonly accompanied by the drainage of existing liquid film between two particles. We observed that the capsules merging in most cases is ac- companied by the formation of dimple surfaces, and thus a simplified flat lubrication surface assumption which is widely-used in the theoretical studies might not be an ideal choice for modeling the film drainage time in merging process.