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End date: 1999Subject: search.filters.subject.Baykousheva

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    Девата на Лангдок [The Lady of Languedoc]
    (1986) Байкушева, Светла; Baykoucheva, Svetla
    The article is devoted to the history of Carcassonne, a fortified town in the South-West of France, and its connection to Bulgarian dualists(bogomils).
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    The long road from chemistry, to microbiology, to information science
    (American Chemical Society, 1999) Baykoucheva, S
    People with nontraditional careers usually find it difficult to explain to others what has driven them through all their professional choices. With an MS in phys. chem., a PhD in microbiology (both earned in Bulgaria), and postdoctoral training, why would someone also translate scientific abstracts and papers, and even a book. Why would a fellow of the International Atomic Energy Agency, while specializing in Paris in the use of isotopes in biochemistry, also write articles about contemporary French intellectuals. Why would a researcher in Ohio State University, while trying to elucidate a metabolic pathway for beta-oxidation of arachidonic acid in peroxisomes, also earn an M.L.S. from Kent State University. Was it only the fascination with chemistry, microbiology, literature, history, linguistics, or the essays published by Eugene Garfield in "Current Contents," that led to a rewarding new career as an information professional and manager of ACS Library.
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    Юджийн Гарфийлд и науката за информацията (Eugene Garfield and information science)
    (1983) Байкушева, Светла; Baykoucheva, Svetla
    Analysis of the contributions made by Eugene Garfield to information science.
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    A moving prose: The "unforgettable novel" of Zelda Fitzgerald
    (1986) Baykoucheva, Svetla; Байкушева, Светла
    Analysis of Zelda Fitzgerald's literary work, including her book "Save me the Waltz," and the relationship of Zelda with her husband Scott Fitzgerald. Discussed is also the relationship of the Fitzgeralds with Ernest Hemingway.
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    Arachidonic acid formed by peroxisomal β-oxidation of 7,10,13,16- docosatetraenoic acid is esterified into 1-acyl-sn-glycero-3-phosphocholine by microsomes
    (American Society for Biochemistry and Molecular Biology, Inc., 1994) Baykousheva, S. P.; Luthria, D. L.; Sprecher, H.
    Peroxisomal beta-oxidation of linoleic acid and arachidonic acid was depressed when 1-palmitoyl-sn-glycero-3-phosphocholine and microsomes were included in incubations. This reduction was due to the esterification of the substrate into the acceptor by microsomal 1-acyl-sn-glycero-3- phosphocholine acyltransferase. The first cycle of the beta-oxidation of 7,10,13,16-docosatetraenoic acid was independent of 1-acyl-sn-glycero-3-phosphocholine and microsomes. However, when arachidonate was produced it was esterified rather than serving as a substrate for continued beta-oxidation. When arachidonate and linoleate were incubated with peroxisomes alone, 2-trans-4,7,10-hexadecatetraenoic acid and 2-trans-4-decadienoic acid were the respective end products of beta-oxidation. 2-Oxo-8,11-heptadecadienone, a catabolite produced from linoleate, was most likely a nonenzymatic decarboxylation product of 3-oxo-9,12-octadecadienoic acid. In addition to the termination of beta-oxidation by microsomal-peroxisomal communication, our results with linoleate and arachidonate suggest that the reaction catalyzed by 2-trans-4-cis-dienoyl-CoA reductase is the control step in double bond removal. In addition, the beta-ketothiolase step may play a regulatory role in the peroxisomal beta-oxidation of linoleate but not arachidonate or 7,10,13,16-docosatetraenoic acid.
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    Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids
    (American Society for Biochemistry and Molecular Biology, Inc., 1995) Sprecher, H; Luthria, D. L..; Mohammed, B. S.; Baykousheva, S. P.
    Recent studies refute the commonly accepted, but untested, hypothesis that 7,10,13,16-22:4 and 7,10,13,16,19-22:5 are desaturated at position 4 by a microsomal acycl-CoA-independent desaturase. The synthesis of 4,7,10,13,16,19-22:6 occurs via the following reaction sequence: 4,7,10,13,16,19-22:6. The synthesis of 4,7,10,10,13,16-22:5 from 7,10,13,16-22:4 takes place via an analogous pathway. According to these pathways the 24-carbon acids that are made in the endoplasmic reticulum move to a site for partial beta-oxidation, 4,7,10,13,16-22:5 and 4,7,10,13,16,19-22:6, then move back to the endoplasmic reticulum where they are used as substrates for membrane lipid biosynthesis. The ability of fatty acid to serve as a substrate for continued peroxisomal beta-oxidation, versus its transfer out of peroxisomes for subsequent endoplasmic reticulum-associated esterification reactions, may be an important control for regulating membrane lipid fatty acid composition. Indeed, the revised pathways of polyunsaturated fatty acid biosynthesis imply that there is considerable intracellular movement endoplasmic reticulum. In addition, these revised pathways require that two 18-carbon and two 24-carbon acids are substrates for desaturation at position 6. Also, as linoleate and linolenate are metabolized, respectively, to 6,9,12,15,18-24:5 and 6,9,12,15,18,21-24:6, three n-6 acids and three n-3 acids are substrates for malonyl-CoA dependent chain elongation. It remains to be determined how many microsomal enzymes ancillary enzymes are expressed in tissues whose membrane lipids accumulate very long-chain polyunsaturated acids with up to 36 carbon atoms.