Theses and Dissertations from UMD

Permanent URI for this communityhttp://hdl.handle.net/1903/2

New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

More information is available at Theses and Dissertations at University of Maryland Libraries.

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Subject: search.filters.subject.Pharmacology

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Now showing 1 - 10 of 37
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    A TISSUE-ENGINEERED PLACENTAL BARRIER MODEL FOR TOXICOLOGY AND PHARMACOLOGY APPLICATIONS
    (2019) Arumugasaamy, Navein; Fisher, John P; Bioengineering; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Throughout history, there have been two major instances where a substance caused thousands of birth defects, yet it took a few years for the causation to be noted: thalidomide, in the late 1950s and early 1960s, and Zika Virus, just recently in 2014 to 2016. In both instances, the developing fetus was indirectly exposed to the substance through the placental barrier. Pregnant women took thalidomide as a medication or were stung by mosquitos and exposed to Zika Virus. These examples clearly show why models of the placental barrier and downstream fetal tissues are critically needed. Herein, I present our work on the development and utilization of a biomimetic placenta-fetus model. The three objectives in this work were to: (1) develop and validate the tissue-engineered BPB model through study of biologically relevant substances; (2) assess the effects of SSRIs on the BPB’s cells and evaluate the drugs’ transport profile across the barrier; and, (3) assess how SSRIs influence cardiomyocyte signaling and injury biomarker release following passage through the BPB. We suggest that this work provides a critically needed and biologically relevant placenta-fetus model, useful as a method to assess pharmacology and toxicology properties of medications and other substances. Moreover, the knowledge gained through the studies performed may hopefully improve clinical care of pregnant women through enhanced understanding of how a medication impacts both the pregnant mother-to-be and her developing fetus.
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    Halogen ring substituted propadrines
    (1942) Zenitz, B. L.; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)
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    Synthetic antimalarials
    (1948) Walton, Edward; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)
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    The pharmacologic actions of theophylline as related to blood levels
    (1950) Truitt, Edward Byrd; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)
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    Introductory study of the effect of enheptin (2-amino, 5-nitrothiazole) on the host-parasite relationship in blackhead
    (1953) Tromba, Francis Gabriel; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)
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    The dehydrogenation of benzyl alcohol in the liquid phase, and the synthesis of intermediates leading to anti-carcinogenic compounds
    (1949) Sterling, John D.; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)
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    Arylvinylamines of pharmacologic interest
    (1952) Stahl, Kenneth Hottenstein; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)
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    The pharmacology and physiology of nitrite and nitrates
    (1942) Rath, Maurice Monroe; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)
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    Synthetic antimalarials
    (1947) Peck, Richard Merle; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)
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    Relationship between "chloramphenicol reductase activity" and chloramphenicol resistance
    (1952) Merkel, Joseph Robert; Digital Repository at the University of Maryland; University of Maryland (College Park, Md)