Theses and Dissertations from UMD

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New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

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Author: search.filters.author.Colvin, Jennifer LynnSubject: search.filters.subject.feline

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    Determination of the dynamics of feline follicle metabolism
    (2013) Colvin, Jennifer Lynn; Bequette, Brian J; Animal Sciences; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    The metabolism of feline follicles has been largely overlooked in reproductive science. The primary objective of this study was to determine differences in metabolite profiles and glucose carbon fluxes in feline follicles of different developmental stages and subjected to different developmental environments. Glycolytic flux, cholesterol (P <0.0001), pyruvic acid (P <0.0001), myo-Inositol (P =0.0003) and proline (P <0.0001) were higher in late versus early antral follicles. Serine (P =0.0085), threonine (P <0.0001), and valine (P =0.0025) were significantly higher in early antral follicles cultured in vitro than those derived directly from feline ovaries; however, glucose carbon flux was not significantly different. The current study suggests that early antral follicles undergo significant metabolic changes before progressing to the late antral stage. While it appears that early antral follicles have diminished capacity to progress to the late antral stage in vitro, it does not appear to be due to fundamental metabolic differences.