Biology Theses and Dissertations
Permanent URI for this collectionhttp://hdl.handle.net/1903/2749
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Item EFFECTS OF AGE ON CONTEXT BENEFIT FOR UNDERSTANDING COCHLEAR-IMPLANT PROCESSED SPEECH(2024) Tinnemore, Anna; Gordon-Salant, Sandra; Goupell, Matthew J; Neuroscience and Cognitive Science; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)The number of people over 65 years old in the United States is rapidly growing as the generation known as “Baby Boomers” reaches this milestone. Currently, at least 16 million of these older adults struggle to communicate effectively because of disabling hearing loss. An increasing number of older adults with hearing loss are electing to receive a cochlear implant (CI) to partially restore their ability to communicate effectively. CIs provide access to speech information, albeit in a highly degraded form. This degradation can frequently make individual words unclear. While predictive sentence contexts can often be used to resolve individual unclear words, there are many factors that either enhance or diminish the benefit of sentence contexts. This dissertation presents three complementary studies designed to address some of these factors, specifically: (1) the location of the unclear word in the context sentence, (2) how much background noise is present, and (3) individual factors such as age and hearing loss. The first study assessed the effect of context for adult listeners with acoustic hearing when a target word is presented in different levels of background noise at the beginning or end of sentences that vary in predictive context. Both context sentences and target words were spectrally degraded as a simulation of sound processed by a CI. The second study evaluated how listeners with CIs use context under the same conditions of background noise, sentence position, and predictive contexts as the group with acoustic hearing. The third study used eye-tracking methodology to infer information about the real-time processing of degraded speech across ages in a group of people who had acoustic hearing and a group of people who used CIs. Results from these studies indicate that target words at the beginning of the context sentence are more likely to be interpreted to be consistent with the following context sentence than target words at the end of the context sentences. In addition, the age of the listener interacted with some of the other experimental variables to predict phoneme categorization performance and response times in both listener groups. In the study of real-time language processing, there were no significant differences in the gaze trajectories between listeners with CIs and listeners with acoustic hearing. Together, these studies confirm that older listeners can use context in a manner similar to younger listeners, although at a slower speed. These studies expand the field’s knowledge of the importance of an unclear word’s location within a sentence and draw attention to the strategies employed by individual listeners to use context. The results of these experiments provide vital data needed to assess the current usage of context in the aging population with CIs and to develop age-specific auditory rehabilitation efforts for improved communication.Item ACUTE EXERCISE INDUCED MICROSTRUCTURAL AND FUNCTIONAL CHANGES IN THE HIPPOCAMPUS OF OLDER ADULTS(2023) Callow, Daniel; Carson, Jerome J; Neuroscience and Cognitive Science; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Declining memory function is a common complaint of aging adults and a primary symptom of mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The hippocampus is often the first brain area to exhibit noticeable deficits in age and pathologically-related cognitive decline and is a necessary structure for proper memory function. More specifically, the dentate gyrus (DG) and the third cornu ammonis area (CA3) of the hippocampus directly support mnemonic discrimination (MD), which is the process of reducing interference among new representations and distinctly encoding them as independent memories. Poor MD is associated with age and is a presymptomatic biomarker of cognitive decline and is believed to result from reduced neurogenesis, angiogenesis, and synaptogenesis within the DG/CA3 subregion of the hippocampus. While causes and treatments for memory decline remain elusive, lifestyle interventions, especially physical activity, have received attention as cost-effective and safe means of ameliorating and potentially preventing cognitive decline in a growing aging population. Animal and human studies suggest exercise benefits the hippocampal structure, preserving neurogenesis and angiogenesis in aging rodents and macrostructure and memory in older adults. However, the mechanisms by which exercise affects the human hippocampus remains a significant knowledge gap in the field and is a critical aspect in understanding the long-term impact exercise has on the aging hippocampus. To better address this gap, researchers have begun implementing acute exercise studies, which allow for greater control of non-exercise-related factors, are cheaper and more time efficient to conduct than training studies, and can predict and inform training-related adaptations. Unfortunately, limitations in the study designs, population tested, specificity of cognitive tasks, and spatial resolution of human imaging techniques have posed significant barriers to our understanding of how acute exercise relates to healthy brain aging at the functional and microstructural levels. Therefore, the objective of this dissertation was to expand our understanding of how acute aerobic exercise alters the function and microstructure of the aging hippocampus. Three within-subject studies were conducted comparing the relationship between a 30-minute bout of moderate to vigorous intensity aerobic exercise vs seated rest on MD performance, hippocampal microstructure, and high-resolution hippocampal-subfield microstructure and functional activity in healthy older adults. In study one, acute exercise preserved MD performance compared to decrements exhibited after seated rest in a pre and post-condition study design. In study two, a post-condition-only study design, acute exercise elevated microstructural diffusion within the hippocampus, indicative of a hippocampal neuroinflammatory response and upregulation of neurotrophic factors. Finally, in study three, a post-condition-only study design, we found that acute exercise resulted in lower MD, suppressed MD-related DG/CA3 network hyperactivity (indicative of healthier network function), and led to higher DG/CA3 extracellular diffusion. However, these neuroimaging-based correlates of hippocampal neuroplasticity and network function were not associated with differences in MD performance. These findings suggest that higher-intensity acute exercise can alter memory performance and stimulate neuroplasticity and neurotrophic cascades within the hippocampus and the DG/CA3 subfield, potentially via different mechanisms. Furthermore these results give insight into the immediate neurotrophic and behavioral effects of acute moderate to vigorous intensity aerobic exercise in older adults and provide new methods and tools for better understanding if and how exercise promotes healthy brain aging. Finally, these initial findings lay a foundation for optimizing exercise prescription and identifying future effective exercise treatments.Item EFFECTS OF AGING ON MIDBRAIN AND CORTICAL SPEECH-IN-NOISE PROCESSING(2016) Presacco, Alessandro; Andreson, Samira; Simon, Jonathan Z.; Neuroscience and Cognitive Science; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Older adults frequently report that they can hear what they have been told but cannot understand the meaning. This is particularly true in noisy conditions, where the additional challenge of suppressing irrelevant noise (i.e. a competing talker) adds another layer of difficulty to their speech understanding. Hearing aids improve speech perception in quiet, but their success in noisy environments has been modest, suggesting that peripheral hearing loss may not be the only factor in the older adult’s perceptual difficulties. Recent animal studies have shown that auditory synapses and cells undergo significant age-related changes that could impact the integrity of temporal processing in the central auditory system. Psychoacoustic studies carried out in humans have also shown that hearing loss can explain the decline in older adults’ performance in quiet compared to younger adults, but these psychoacoustic measurements are not accurate in describing auditory deficits in noisy conditions. These results would suggest that temporal auditory processing deficits could play an important role in explaining the reduced ability of older adults to process speech in noisy environments. The goals of this dissertation were to understand how age affects neural auditory mechanisms and at which level in the auditory system these changes are particularly relevant for explaining speech-in-noise problems. Specifically, we used non-invasive neuroimaging techniques to tap into the midbrain and the cortex in order to analyze how auditory stimuli are processed in younger (our standard) and older adults. We will also attempt to investigate a possible interaction between processing carried out in the midbrain and cortex.