UMD Theses and Dissertations
Permanent URI for this collectionhttp://hdl.handle.net/1903/3
New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a given thesis/dissertation in DRUM.
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Item A Movement Account of Long-Distance Reflexives(2013) McKeown, Rebecca Katherine; Hornstein, Norbert R; Linguistics; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)This thesis examines reflexive pronouns, such as Icelandic sig (Cf. Thráinsson 2007), which may be bound from outside of an infinitive clause (which I call MD "medium distance" binding) in addition to being bound locally. I propose that such reflexives are linked to their antecedents via sisterhood followed by movement: the reflexive and antecedent are first merged together as sisters, and the antecedent subsequently moves to receive its first theta-role, as schematized below: 1. He ordered Harold to shave he+sig This links the properties of bound simplex reflexives to the properties of movement. I argue that reflexives such as sig must be bound within the first finite clause because finite CP is a spell-out domain and its escape hatch is inaccessible to A-movement. Furthermore, I derive the subject-orientation of sig and other simplex reflexives from merge-over-move, combined with a numeration divided into phases including vP. Since the antecedent is moving into its first theta-role, and merge is preferable to move, the antecedent will end up in the highest position in the phase: that is, the subject. I then examine long-distance (LD) uses of sig as well as Chinese ziji, Japanese zibun, and Kannada tannu. I propose that in such cases the reflexive still has a double, which is not the antecedent but a null element, possibly an operator. It undergoes A' movement to a position in the left periphery of a finite clause, associated with point-of- view (with a divided left periphery as in Speas 2004)--and this operator is in turn associated with an antecedent either outside the finite clause, or outside the sentence entirely. This accounts for the observation that LD reflexives often must refer to POV holders (Sells 1987). Evidence for LD reflexives being mediated by an A' position comes from the interaction of binding with wh-movement in Kannada (Lidz 2008), and is one way of describing where blocking effects do and do not occur in Chinese (Anand 2006). Furthermore, in Japanese there are sometimes overt morphemes, potentially left- periphery heads, that indicate POV and can co-occur with the use of LD reflexives (Nishigauchi 2005, 2010).Item Patterns and Complexity in Biological Systems: A Study of Sequence Structure and Ontology-based Networks(2010) Glass, Kimberly; Girvan, Michelle; Physics; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)Biological information can be explored at many different levels, with the most basic information encoded in patterns within the DNA sequence. Through molecular level processes, these patterns are capable of controlling the states of genes, resulting in a complex network of interactions between genes. Key features of biological systems can be determined by evaluating properties of this gene regulatory network. More specifically, a network-based approach helps us to understand how the collective behavior of genes corresponds to patterns in genetic function. We combine Chromatin-Immunoprecipitation microarray (ChIP-chip) data with genomic sequence data to determine how DNA sequence works to recruit various proteins. We quantify this information using a value termed "nmer-association.'' "Nmer-association'' measures how strongly individual DNA sequences are associated with a protein in a given ChIP-chip experiment. We also develop the "split-motif'' algorithm to study the underlying structural properties of DNA sequence independent of wet-lab data. The "split-motif'' algorithm finds pairs of DNA motifs which preferentially localize relative to one another. These pairs are primarily composed of known transcription factor binding sites and their co-occurrence is indicative of higher-order structure. This kind of structure has largely been missed in standard motif-finding algorithms despite emerging evidence of the importance of complex regulation. In both simple and complex regulation, two genes that are connected in a regulatory fashion are likely to have shared functions. The Gene Ontology (GO) provides biologists with a controlled terminology with which to describe how genes are associated with function and how those functional terms are related to each other. We introduce a method for processing functional information in GO to produce a gene network. We find that the edges in this network are correlated with known regulatory interactions and that the strength of the functional relationship between two genes can be used as an indicator of how informationally important that link is in the regulatory network. We also investigate the network structure of gene-term annotations found in GO and use these associations to establish an alternate natural way to group the functional terms. These groups of terms are drastically different from the hierarchical structure established by the Gene Ontology and provide an alternative framework with which to describe and predict the functions of experimentally identified groups of genes.Item Role of Human Parietal and Premotor Cortical Areas in Complex Hand Movements(2005-04-11) Wheaton, Lewis A; Cohen, Avis; Neuroscience and Cognitive Science; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)The need to understand our ability to plan and successfully execute movement is a core aspect of clinical neurophysiology. Studies in humans are particularly valuable and can have direct application to neurological disorders. While most studies have focused on the physiological characteristics of relatively simple movements (e.g., finger flexion, extension), the aim of the current studies is to determine the mechanisms involved in producing meaningful, complex movements that better represent natural movements. Electroencephalography (EEG) measures such as movement-related cortical potentials, coherence, and event-related synchronization and desynchronization allow investigators to determine the functions of specific areas and coherent networks before and during movement. Patients with ideomotor apraxia, who produce abnormal movements with spatial and/or temporal errors during pantomime of praxis movements (e.g., using a hammer, waving good-bye), were compared to normal subjects. It is our hypothesis that performance of complex movements involves early preparatory activity seen localized in the left parietal and premotor cortical areas. Additionally, we hypothesize that the activity seen in the parietal and premotor cortices is coherent and part of a functional network for such movements. Stroke patients with parietal and premotor lesions with apraxia will show a decrease in function of these areas, as well as reduced communication of the network as a result of their anatomical damage. Our studies revealed widespread and early activity of the parietal cortex for praxis movements in normal subjects. This early activity was also seen in the inferior temporal cortex. The distribution and timing of this activity was different when comparing it to simple movements, which generally had activity confined to the premotor cortex. Moreover, an active functional network was seen between the parietal and premotor cortices of the left hemisphere for praxis movements. This network differed from that seen in patients with ideomotor apraxia, where activity in the right hemisphere parietal and premotor areas became predominant. These studies provide evidence of distinct and early parietal activity before praxis and a functional network that is involved in planning and execution, which can be modified in the event of brain injury.