UMD Theses and Dissertations

Permanent URI for this collectionhttp://hdl.handle.net/1903/3

New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a given thesis/dissertation in DRUM.

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Author: search.filters.author.Yew, Alvin GarwaiSubject: search.filters.subject.cell proliferation

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    The Equilibrium Geometry Theory for Bone Fracture Healing
    (2008-04-29) Yew, Alvin Garwai; Hsieh, Adam H; Mechanical Engineering; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Models describing the impact of mechanical stimuli on bone fracture healing can be used to design improved fixation devices and optimize clinical treatment. Existing models however, are limited because they fail to consider the changing fracture callus morphology and probabilistic behavior of biological systems. To resolve these issues, the Equilibrium Geometry Theory (EGT) was conceptualized and when coupled with a mechanoregulation algorithm for differentiation, it provides a way to simulate cell processes at the fracture site. A three-dimensional, anisotropic random walk model with an adaptive finite element domain was developed for studying the entire course of fracture healing based on EGT fundamentals. Although a coarse cell dispersal lattice and finite element mesh were used for analyses, the computational platform provides exceptional latitude for visualizing the growth and remodeling of tissue. Preliminary parameter and sensitivity studies show that simulations can be fine-tuned for a wide variety of clinical and research applications.