UMD Theses and Dissertations

Permanent URI for this collectionhttp://hdl.handle.net/1903/3

New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a given thesis/dissertation in DRUM.

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Author: search.filters.author.Valencia, Ana PatriciaSubject: search.filters.subject.Cellular biology

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    Association between increased hepatic lipid storage and impaired hepatic mitochondrial function in ovariectomized mice
    (2012) Valencia, Ana Patricia; Spangenburg, Espen E; Kinesiology; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Reduced ovarian function is associated with development of the metabolic syndrome (MetS). Increased risk for MetS is strongly linked to hepatic metabolic dysfunction. However, at this time few studies have examined metabolic function of hepatic tissue under conditions of reduced ovarian function. The purpose of this study was to determine if ovariectomy (OVX) impaired hepatic mitochondrial function and its potential association with sirtuin (SIRT) function. Female C57BL/6 mice were divided into two groups (SHAM, OVX). Hepatic mitochondrial function was measured by assessing oxygen consumption, reactive oxygen species (ROS) production, and mitochondrial protein content. In addition, mitochondrial acetylation status and SIRT protein content was determined. The OVX group exhibited increased ROS production compared to the SHAM group. However, no differences were detected in oxygen consumption, mitochondrial protein content, acetylation status, or total SIRT content between groups. The data shows that ovariectomy increases mitochondrial ROS production, which suggests a novel mechanism to consider.