UMD Theses and Dissertations

Permanent URI for this collectionhttp://hdl.handle.net/1903/3

New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a given thesis/dissertation in DRUM.

More information is available at Theses and Dissertations at University of Maryland Libraries.

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Author: search.filters.author.Sorrell, Erin MaureenSubject: search.filters.subject.Biology, Molecular

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    Adaptation of A/Mallard/Potsdam/178-4/83 (H2N2) in Japanese quail leads to Replication and Transmission in Chickens
    (2005-05-02) Sorrell, Erin Maureen; Perez, Daniel R; Animal Sciences; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Influenza is a single stranded, negative-sense RNA virus with a segmented genome that can infect avian and mammalian species. Influenza viruses from the avian reservoir do not seem to replicate efficiently in humans upon direct transmission. Therefore, an intermediate host is involved in generating mutations to create a more transmissible or an avian-human reassortant virus. Quail have been highlighted as a potential reservoir and intermediate host of avian influenza. To assess the potential of quail as an intermediate host, A/Mallard/Postdam/178-4/83, H2N2 was tested to determine if through adaptation in quail a mallard strain can replicate and transmit in quail, as well as other avian species. After six serial passages of lung homogenate a virus arose, which replicated and transmitted directly to contact quail. When chickens were infected with this quail-adapted virus replication and transmission were observed, while no replication was noted in the chickens infected with wild type H2N2 virus.