UMD Theses and Dissertations

Permanent URI for this collectionhttp://hdl.handle.net/1903/3

New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a given thesis/dissertation in DRUM.

More information is available at Theses and Dissertations at University of Maryland Libraries.

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Author: search.filters.author.Haque, Mefruz SalwaSubject: search.filters.subject.metabolic syndrome

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    Associations between Urinary Phthalates and Metabolic Syndrome in NHANES 2005-2010
    (2015) Haque, Mefruz Salwa; Dallal, Cher M; Epidemiology and Biostatistics; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Phthalates, commonly used to make plastics more durable, are a group of endocrine disrupting chemicals (EDC), with potential for adverse metabolic consequences. Associations between exposure to 13 phthalate metabolites and the prevalence of metabolic syndrome (MetS) were examined among 5,409 U.S adults ≥ 18 years of age, who participated in the National Health and Nutrition Examination Survey from 2005-2010. MetS was assessed using clinical and questionnaire data. Odds Ratio (OR) and 95% Confidence Intervals (CI) adjusting for age, creatinine and key confounders, were estimated with multivariable logistic regression. Positive associations were observed between individual phthalate metabolites and MetS: (MCOP OR=1.31, 95% CI=1.40, 1.64, p-trend<.01; MCPP OR=1.39, 95% CI=1.09, 1.77, p-trend=0.01). In gender stratified analyses, findings with MCOPP and MCPP were restricted to women only. Phthalate metabolites may increase the prevalence of MetS; however, further studies are needed to better understand the role of EDCs in the development of MetS.