UMD Theses and Dissertations

Permanent URI for this collectionhttp://hdl.handle.net/1903/3

New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a given thesis/dissertation in DRUM.

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Author: search.filters.author.Carr, Erikka LynnetteSubject: search.filters.subject.glutamine metabolism

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    Regulation of glutamine utilization during T cell activation
    (2007-08-13) Carr, Erikka Lynnette; Frauwirth, Kenneth; Cell Biology & Molecular Genetics; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Activation of a naïve T cell is a highly energetic event, which requires an increase in metabolism. Upon stimulation, T cells increase in size, rapidly proliferate and differentiate, all of which lead to a high demand for energetic and biosynthetic precursors. Even though amino acids are the basic building blocks of protein biosynthesis, the role of amino acid metabolism in this process has not been well characterized. We have found that glutamine in particular is required for both proliferative as well as effector function. We have evidence that glutamine regulates ERK signaling and that ERK in turn may also regulate glutamine transport. These data indicate that glutamine may play a significant role in T cell signaling and that a better understanding of glutamine utilization in T cells may reveal novel targets for immunomodulatory and/or anti-leukemia therapy.