Minority Health and Health Equity Archive

Permanent URI for this collectionhttp://hdl.handle.net/1903/21769

Welcome to the Minority Health and Health Equity Archive (MHHEA), an electronic archive for digital resource materials in the fields of minority health and health disparities research and policy. It is offered as a no-charge resource to the public, academic scholars and health science researchers interested in the elimination of racial and ethnic health disparities.

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Author: search.filters.author.Benjamin, Emelia J.Subject: search.filters.subject.Health Risk Factors

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    Association of Parental Heart Failure with Risk of Heart Failure in Offspring
    (2006) Lee, Douglas S.; Pencina, Michael J.; Benjamin, Emelia J.; Wang, Thomas J.; Levy, Daniel; O’Donnell, Christopher J.; Nam, Byung-Ho; Larson, Martin G.; D’Agostino, Ralph B.; Vasan, Ramachandran S.
    Background The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting. Methods We examined the cross-sectional association of heart failure in parents with the prevalence of left ventricular systolic dysfunction, as well as left ventricular mass, internal dimensions, and wall thickness, in 1497 participants of the Framingham Offspring Study (mean age, 57 years; 819 women) who underwent routine echocardiography. We also investigated prospectively whether heart failure in parents increased the risk of heart failure in 2214 offspring (mean age, 44 years; 1150 women). Results As compared with the 1039 participants whose parents did not have heart failure, the 458 participants in the cross-sectional cohort who had at least one parent with heart failure were more likely to have increased left ventricular mass (17.0 percent vs. 26.9 percent), left ventricular internal dimensions (18.6 percent vs. 23.4 percent), and left ventricular systolic dysfunction (3.1 percent vs. 5.7 percent); the multivariable- adjusted odds ratios were 1.35 (95 percent confidence interval, 0.99 to 1.84), 1.29 (95 percent confidence interval, 0.96 to 1.72), and 2.37 (95 percent confidence interval, 1.22 to 4.61), respectively. In the longitudinal cohort, heart failure developed in 90 offspring during follow-up (mean length of follow-up, 20 years). The age- and sex adjusted 10-year incidence rates of heart failure were 2.72 percent among offspring with a parent with heart failure, as compared with 1.62 percent among those without a parent with heart failure. This increase in risk persisted after multivariable adjustment (hazard ratio, 1.70; 95 percent confidence interval, 1.11 to 2.60). Conclusions Heart failure in parents is associated with an increased prevalence of left ventricular systolic dysfunction cross-sectionally and an elevated risk of heart failure longitudinally. Our data emphasize the contribution of familial factors to the heart failure burden in the community.
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    Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women: 2007 Update
    (2007) Mosca, Lori; Banka, Carole L.; Benjamin, Emelia J.; Berra, Kathy; Bushnell, Cheryl; Dolor, Rowena J.; Ganiats, Theodore G.; Gomes, Antoinette S.; Gornik, Heather L.; Gracia, Clarissa; Gulati, Martha; Haan, Constance K.; Judelson, Debra R.; Keenan, Nora; Kelepouris, Ellie; Michos, Erin D.; Newby, L. Kristin; Oparil, Suzanne; Ouyang, Pamela; Oz, Mehmet C; Diana Petitti, Diana; Pinn, Vivian W.; Redberg, Rita F.; Scott, Rosalyn; Sherif, Katherine; Smith, Sidney C.; Sopko, George; Steinhorn, Robin H.; Stone, Neil J.; Taubert, Kathryn A..; Todd, Barbara A.; Urbina, Elaine; Wenger, Nanette K.
    Worldwide, cardiovascular disease (CVD) is the largest single cause of death among women, accounting for one third of all deaths. In many countries, including the United States, more women than men die every year of CVD, a fact largely unknown by physicians. The public health impact of CVD in women is not related solely to the mortality rate, given that advances in science and medicine allow many women to survive heart disease. For example, in the United States, 38.2 million women (34%) are living with CVD, and the population at risk is even larger. In China, a country with a population of approximately 1.3 billion, the age-standardized prevalence rates of dyslipidemia and hypertension in women 35 to 74 years of age are 53% and 25%, respectively, which underscores the enormity of CVD as a global health issue and the need for prevention of risk factors in the first place. As life expectancy continues to increase and economies become more industrialized, the burden of CVD on women and the global economy will continue to increase.