In computational fluid dynamics (CFD) fire models, sprinkler sprays are represented in complex numerical simulations using Lagrangian particles. These CFD sprays are typically characterized using a combination of experimental data, literature correlations, and estimation. The Spatially-Resolved Spray Scanning System (4S) machine provides high resolution data to characterize sprays for use in CFD analysis, however a quantitative analysis on the effect of this high resolution data with FDS in realistic fire scenarios has not been completed before. 4S spray data is analyzed and compared to a basic spray estimated from literature correlations with and without the presence of fire to analyze trends. In all environments, the basic nozzle overestimated water flux closer to the center of the nozzle and underestimated water flux farther from the center. Differences between the basic and 4S nozzle ranged from 1% to 240% in the enclosure fire scenario. Investigation into the differences showed the polar water distribution to be the most impactful parameter provided by the 4S. Local azimuthal trends were shown to be significant, but non-impactful in the enclosure fire simulation. Global azimuthal trends were apparent but not significant.